Telomere dynamics in arteries and mononuclear cells of diabetic patients: Effect of diabetes and of glycemic control
Telomere dynamics in arteries and mononuclear cells of diabetic patients: Effect of diabetes and of glycemic control
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DOI：
10.1016/j.exger.2007.07.005
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发表时间：
2007-10-01
影响因子：
3.9
通讯作者：
Lahav, Meir
中科院分区：
文献类型：
--
作者：
Uziel, Orit;Singer, Joelle Attal;Lahav, Meir
端粒作为有丝分裂时钟和衰老的生物标志。糖尿病 (DM) 与靶器官损伤和过早衰老有关。我们评估了血糖控制对 58 名接受冠状动脉搭桥术的患者的动脉细胞和其他糖尿病患者（32 名 I 型和 47 名 II 型）的单核血细胞的端粒动态的影响，并将控制良好的患者与未控制的患者进行比较。所有这些都与健康对照的年龄依赖性曲线进行比较。与非糖尿病患者相比，糖尿病患者的动脉以及 I 型和 II 型糖尿病的单核细胞中的端粒明显较短 (p = 0.049)。在所有研究组中，良好的血糖控制减弱了端粒的缩短。在动脉细胞中，良好的血糖控制会减弱但不会消除端粒缩短。在 II 型糖尿病中，充分的血糖控制可以完全防止单核端粒磨损。 I型糖尿病患者单核细胞的端粒缩短被减弱，但良好的血糖控制并不能阻止这种现象。这项研究的结果表明，糖尿病与细胞过早衰老有关，对于 II 型糖尿病来说，良好的血糖控制可以预防这种情况，而对于 I 型糖尿病来说，可以减少这种情况。 (C) 2007 Elsevier Inc. 保留所有权利。
Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cells of other diabetic (32 type I and 47 type II) patients comparing well controlled to uncontrolled patients. All were compared to age-dependent curve of healthy controls. Telomeres were significantly shorter in the arteries of diabetic versus non-diabetic patients (p = 0.049) and in mononuclear cells of both type I and type II diabetes. In all study groups good glycemic control attenuated shortening of the telomeres. In arterial cells good glycemic control attenuated, but not abolished, the telomere shortening. In type II DM the mononuclear telomere attrition was completely prevented by adequate glycemic control. Telomere shortening in mononuclear cells of type I diabetic patients was attenuated but not prevented by good glycemic control. Results of this study suggest that diabetes is associated with premature cellular senescence which can be prevented by good glycemic control in type II DM, and reduced in type I DM. (C) 2007 Elsevier Inc. All rights reserved.