Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer.
Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer.
复制标题
HE4（人附睾蛋白4）过度表达增强卵巢癌的增殖、侵袭和转移
DOI：
10.18632/oncotarget.6327
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发表时间：
2016-01-05
期刊：
影响因子：
--
通讯作者：
Lin B
中科院分区：
文献类型：
--
作者：
Zhu L;Zhuang H;Wang H;Tan M;Schwab CL;Deng L;Gao J;Hao Y;Li X;Gao S;Liu J;Lin B
Overexpression of Human epididymis protein 4 (HE4) related with a role in ovarian cancer tumorigenesis while little is known about the molecular mechanism alteration by HE4 up regulation. Here we reported that overexpressed HE4 promoted ovarian cancer cells proliferation, invasion and metastasis. Furthermore, human whole genome gene expression profile microarrays revealed that 231 differentially expressed genes (DEGs) were altered in response to HE4, in which MAPK signaling, ECM receptor, cell cycle, steroid biosynthesis pathways were involved. The findings suggested that overexpressed HE4 played an important role in ovarian cancer progression and metastasis and that HE4 has the potential to serve as a novel therapeutic target for ovarian cancer.
