The Bladder EpiCheck Test as a Non-Invasive Tool Based on the Identification of DNA Methylation in Bladder Cancer Cells in the Urine: A Review of Published Evidence.
The Bladder EpiCheck Test as a Non-Invasive Tool Based on the Identification of DNA Methylation in Bladder Cancer Cells in the Urine: A Review of Published Evidence.
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膀胱EpiCheck测试作为一种基于尿液中膀胱癌细胞DNA甲基化鉴定的非侵入性工具：对已发表证据的回顾。
DOI：
10.3390/ijms21186542
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发表时间：
2020-09-08
影响因子：
5.6
通讯作者：
Zattoni F
中科院分区：
文献类型：
--
作者：
Mancini M;Righetto M;Zumerle S;Montopoli M;Zattoni F
Recently, there has been a great effort to develop tests based on non-invasive urinary biomarkers (NMIBCs). These tests are based on the fact that NMIBCs are heterogeneous at the molecular level and can be divided into different molecular groups useful to predict prognosis and response to treatment. The assessment of epigenetic alterations, such as DNA methylation, represents a promising cancer biomarker. DNA methylation is an epigenetic modification that affects gene expression without modifying the DNA sequence. Several studies have highlighted the presence of methylated loci in the context of bladder cancer, indicating its potential application as a diagnostic and prognostic biomarker. One of the novel assays based on a DNA methylation profile, the Bladder EpiCheck, analyzes DNA from spontaneous urine, detecting disease-specific DNA methylation patterns in bladder cancer patients. This test, due to its non-invasive nature and highly promising performance could, in future, become an invaluable tool in the follow-up of bladder cancer patients. Potential new applications could include diagnosis and surveillance of upper-tract disease, for the replacement of invasive testing and ureteroscopy.
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影响因子：
8.2
作者：
Witjes, J. Alfred;Morote, Juan;Leibovitch, Ilan
通讯作者：
Leibovitch, Ilan
DOI：
10.1016/j.urolonc.2009.11.004
发表时间：
2010-07-01
影响因子：
2.7
作者：
Lotan, Yair;Shariat, Shahrokh F.;Grossman, H. Barton
通讯作者：
Grossman, H. Barton
影响因子：
4.5
作者：
Pichler, Renate;Fritz, Josef;Heidegger, Isabel
通讯作者：
Heidegger, Isabel
影响因子：
23.4
作者：
Leal, Jose;Luengo-Fernandez, Ramon;Witjes, J. Alfred
通讯作者：
Witjes, J. Alfred
影响因子：
3.4
作者：
Trenti, Emanuela;Pycha, Stefan;D'Elia, Carolina
通讯作者：
D'Elia, Carolina