Characteristics of Health Information Gatherers, Disseminators, and Blockers Within Families at Risk of Hereditary Cancer: Implications for Family Health Communication Interventions
Characteristics of Health Information Gatherers, Disseminators, and Blockers Within Families at Risk of Hereditary Cancer: Implications for Family Health Communication Interventions
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DOI：
10.2105/ajph.2008.154096
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发表时间：
2009-12-01
影响因子：
12.7
通讯作者：
Greene, Mark H.
中科院分区：
文献类型：
--
作者：
Koehly, Laura M.;Peters, June A.;Greene, Mark H.
目标.鉴于传播准确的家族史以评估疾病风险的重要性，我们描述了具有高遗传癌症风险的家庭中健康信息的收集者、传播者和阻断者。通过使用彩色生态遗传关系图（CEGRM），确定了来自124个BRCA 1/2基因突变（与乳腺癌、卵巢癌和其他类型癌症的高风险相关）家庭的183名女性乳腺成像研究参与者的5466名个人网络成员。分层非线性模型拟合的信息收集者，传播者和阻断者的特征。信息收集者多为女性（P
Objectives. Given the importance of the dissemination of accurate family history to assess disease risk, we characterized the gatherers, disseminators, and blockers of health information within families at high genetic risk of cancer.Methods. A total of 5466 personal network members of 183 female participants of the Breast Imaging Study from 124 families with known mutations in the BRCA1/2 genes (associated with high risk of breast, ovarian, and other types of cancer) were identified by using the Colored Eco-Genetic Relationship Map (CEGRM). Hierarchical nonlinear models were fitted to characterize information gatherers, disseminators, and blockers.Results. Gatherers of information were more often female (P