The behavior of skin grafts incompatible with respect to skin alloantigens on mice rendered tolerant at birth with lymphoid cells.
The behavior of skin grafts incompatible with respect to skin alloantigens on mice rendered tolerant at birth with lymphoid cells.
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DOI：
10.1084/jem.143.6.1317
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发表时间：
1976-06-01
期刊：
影响因子：
--
通讯作者：
Poole TW
中科院分区：
文献类型：
--
作者：
Silvers WK;Wachtel SS;Poole TW
据报道，经（A X B6）造血细胞恢复的成年B6小鼠经过致命照射后，随后会排斥成人A株皮肤移植物，因为它们对A株皮肤特异性（Sk）抗原不耐受。这一观点已经被一系列的新生动物实验所证实。因此，亚致死照射新生B6小鼠，接种（A × B6）淋巴样细胞，永久接受这些细胞，随后排斥成人A株皮肤移植物。进一步的证据表明，这些移植物的破坏是由宿主对Sk抗原的反应引起的，这一事实提供了类似处理的受体通常永久接受新生儿A株皮肤。这种移植物通常诱导对成人a系皮肤移植物的耐受性。
It has been reported that lethally irradiated adult B6 mice restored with (A X B6) hemopoietic cells subsequently reject adult A-strain skin grafts because they are not tolerant of A-strain skin-specific (Sk) antigens. This thesis has been confirmed by a series of experiments conducted on neonatally treated animals. Thus sublethally irradiated neonatal B6 mice, inoculated with (A X B6) lymphoid cells, permanently accept these cells while subsequently rejecting adult strain A skin grafts. Further evidence that the destruction of these grafts results from the reaction of the host to Sk antigens, is provided by the fact that similarly treated recipients often permanently accept neonatal A- strain skin. Such grafts usually induce tolerance of adult A-strain skin grafts.