Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer's disease.
Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer's disease.
复制标题
DOI：
10.2147/ndt.s55371
复制
发表时间：
2014
影响因子：
3.2
通讯作者：
Forlenza OV
中科院分区：
文献类型：
--
作者：
Pereira ML;Camargo Mv;Aprahamian I;Forlenza OV
大量的研究已经围绕最能预测阿尔茨海默病（AD）发作的早期认知障碍展开。鉴于轻度认知障碍（MCI）不再被认为是正常衰老和AD之间的中间状态，因此已经追踪了新的途径来获得有关这种疾病及其亚型的进一步知识，并确定其中哪些疾病转化为AD的风险更高。现在已知，除了情景和语义记忆障碍之外，其他缺陷可能存在于AD的早期阶段，例如视觉空间和执行功能缺陷。此外，最近的研究表明，海马和内侧颞叶结构不仅参与记忆功能，而且还参与视觉过程。这些记忆、视觉和执行过程的早期变化也可以通过研究MCI和AD等病理条件下的眼动模式来检测。在本综述中，我们试图探讨现有的文献中关于这些模式的oculably的变化，以及这些变化是如何与AD的早期迹象。特别是，我们认为，赤字的视觉短期记忆，特别是在图像记忆，注意力的过程，和抑制控制，可能会发现通过眼动模式的分析，我们讨论他们如何可能有助于预测进展MCI到AD。我们补充说，在这些条件下的眼动模式的研究，结合神经成像技术和适当的神经心理学任务的基础上严格的概念来自认知心理学，可能会突出的早期存在的认知障碍的过程中的疾病。
A great amount of research has been developed around the early cognitive impairments that best predict the onset of Alzheimer’s disease (AD). Given that mild cognitive impairment (MCI) is no longer considered to be an intermediate state between normal aging and AD, new paths have been traced to acquire further knowledge about this condition and its subtypes, and to determine which of them have a higher risk of conversion to AD. It is now known that other deficits besides episodic and semantic memory impairments may be present in the early stages of AD, such as visuospatial and executive function deficits. Furthermore, recent investigations have proven that the hippocampus and the medial temporal lobe structures are not only involved in memory functioning, but also in visual processes. These early changes in memory, visual, and executive processes may also be detected with the study of eye movement patterns in pathological conditions like MCI and AD. In the present review, we attempt to explore the existing literature concerning these patterns of oculomotor changes and how these changes are related to the early signs of AD. In particular, we argue that deficits in visual short-term memory, specifically in iconic memory, attention processes, and inhibitory control, may be found through the analysis of eye movement patterns, and we discuss how they might help to predict the progression from MCI to AD. We add that the study of eye movement patterns in these conditions, in combination with neuroimaging techniques and appropriate neuropsychological tasks based on rigorous concepts derived from cognitive psychology, may highlight the early presence of cognitive impairments in the course of the disease.