The 'Digital Twin' to enable the vision of precision cardiology.
The 'Digital Twin' to enable the vision of precision cardiology.
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DOI:
10.1093/eurheartj/ehaa159
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发表时间:
2020-12-21
影响因子:
39.3
通讯作者:
Lamata P
中科院分区:
文献类型:
--
作者:
Corral-Acero J;Margara F;Marciniak M;Rodero C;Loncaric F;Feng Y;Gilbert A;Fernandes JF;Bukhari HA;Wajdan A;Martinez MV;Santos MS;Shamohammdi M;Luo H;Westphal P;Leeson P;DiAchille P;Gurev V;Mayr M;Geris L;Pathmanathan P;Morrison T;Cornelussen R;Prinzen F;Delhaas T;Doltra A;Sitges M;Vigmond EJ;Zacur E;Grau V;Rodriguez B;Remme EW;Niederer S;Mortier P;McLeod K;Potse M;Pueyo E;Bueno-Orovio A;Lamata P
Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the ‘digital twin’ of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.
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影响因子:
24
作者:
Dey, Pranammya;Ross, Joseph S.;Krumholz, Harlan M.
通讯作者:
Krumholz, Harlan M.
影响因子:
10.9
作者:
Donati, Fabrizio;Figueroa, C. Alberto;Nordsletten, David A.
通讯作者:
Nordsletten, David A.
DOI:
10.1161/circimaging.116.005207
发表时间:
2017-01
期刊:
Circulation. Cardiovascular imaging
影响因子:
--
作者:
Donati F;Myerson S;Bissell MM;Smith NP;Neubauer S;Monaghan MJ;Nordsletten DA;Lamata P
通讯作者:
Lamata P
DOI:
10.1016/0735-1097(90)90225-e
发表时间:
1990-04-01
影响因子:
24
作者:
ALFONSO, F;ANNOPOULOS, PN;MCKENNA, WJ
通讯作者:
MCKENNA, WJ
影响因子:
6.1
作者:
Cedilnik, Nicolas;Duchateau, Josselin;Sermesant, Maxime
通讯作者:
Sermesant, Maxime