Determination of Sample Concentrations by PULCON NMR Spectroscopy.

Determination of Sample Concentrations by PULCON NMR Spectroscopy.
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DOI:
10.1071/ch21149
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发表时间:
2022
影响因子:
1.1
通讯作者:
Mak JYW
Mak JYW
中科院分区:
化学4区
文献类型:
--
作者:
Mak JYW

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PULCON (Pulse Length Based Concentration Determination) is a powerful, versatile, non-invasive, and accurate technique for measuring solution concentrations during routine NMR spectroscopy. As solutes are quantified directly by their unique resonances, this technique avoids weight-based errors caused by contaminants (e.g. moisture), allows NMR samples to be directly employed in biological assays, and is particularly useful for quantifying small molecules, peptides, unstable molecules, and other materials that are difficult to weigh or handle. This article provides an introductory guide for biological and medicinal chemists, and highlights the diversity of applications.
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