Preoperative versus postoperative chemo-radiotherapy for locally advanced gastric cancer: a multicenter propensity score-matched analysis.
Preoperative versus postoperative chemo-radiotherapy for locally advanced gastric cancer: a multicenter propensity score-matched analysis.
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局部进展期胃癌术前与术后放化疗的比较：多中心倾向评分匹配分析
DOI：
10.1186/s12885-022-09297-7
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发表时间：
2022-02-26
期刊：
影响因子：
3.8
通讯作者：
Jin J
中科院分区：
文献类型：
--
作者：
Li N;Xiang X;Zhao D;Wang X;Tang Y;Chi Y;Yang L;Jiang L;Jiang J;Shi J;Liu W;Fang H;Tang Y;Chen B;Lu N;Jing H;Qi S;Wang S;Liu Y;Song Y;Li Y;Zhang L;Jin J
围手术期放化疗在局部进展期胃癌中起重要作用。与术后治疗相比，术前策略是否能改善长期预后尚不清楚。本研究旨在比较局部晚期胃癌患者术前放化疗（pre-CRT）和术后放化疗（post-CRT）的肿瘤学结局。从2009年1月至2019年4月，纳入了来自2个中心的222例接受CRT前和CRT后治疗的T3/4期和/或N阳性胃癌患者。倾向评分匹配（PSM）后，采用Kaplan-Meier分析和对数秩检验比较CRT前和后组的局部区域控制（LC）、无远处转移生存期（DMFS）、无疾病生存期（DFS）和总生存期（OS）。中位随访期为30个月。生成120个匹配病例进行分析。CRT前与CRT后组的3年LC、DMFS、DFS和OS分别为93.8%与97.2%（p = 0.244）、78.7%与65.7%（p = 0.017）、74.9%与65.3%（p = 0.042）和74.4%与61.2%（p = 0.055）。单因素和多因素分析显示，CRT前与DFS显著相关。与术后CRT相比，术前CRT显示出肿瘤学结局的优势。ClinicalTrial.gov NCT 01291407、NCT 03427684和NCT 04062058，注册日期：2011年2月8日。
Peri-operative chemo-radiotherapyplayed important rolein locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear. The study purpose to compare oncologic outcomes in locally advanced gastric cancer patients treated with preoperative chemo-radiotherapy (pre-CRT) and postoperative chemo-radiotherapy (post-CRT). From January 2009 to April 2019, 222 patients from 2 centers with stage T3/4 and/or N positive gastric cancer who received pre-CRT and post-CRT were included. After propensity score matching (PSM), comparisons of local regional control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) were performed using Kaplan-Meier analysis and log-rank test between pre- and post-CRT groups. The median follow-up period was 30 months. 120 matched cases were generated for analysis. Three-year LC, DMFS, DFS and OS for pre- vs. post-CRT groups were 93.8% vs. 97.2% (p = 0.244), 78.7% vs. 65.7% (p = 0.017), 74.9% vs. 65.3% (p = 0.042) and 74.4% vs. 61.2% (p = 0.055), respectively. Pre-CRT were significantly associated with DFS in uni- and multi-variate analysis. Preoperative CRT showed advantages of oncologic outcome compared with postoperative CRT. ClinicalTrial.gov NCT01291407, NCT03427684 and NCT04062058, date of registration: Feb 8, 2011.
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影响因子：
51.1
作者：
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