Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
复制标题
DOI：
10.3892/ijo.22.3.469
复制
发表时间：
2003-03
影响因子：
5.2
通讯作者：
F. Chang;L. Steelman;J. G. Shelton;John T. Lee;P. Navolanic;W. Blalock;R. Franklin;J. McCubrey
中科院分区：
文献类型：
--
作者：
F. Chang;L. Steelman;J. G. Shelton;John T. Lee;P. Navolanic;W. Blalock;R. Franklin;J. McCubrey
Ras/Raf/MEK/ERK信号转导通路调节不同类型细胞的细胞周期进程和凋亡。这种途径的突变经常在转化细胞系中观察到，并且经常与人类癌症有关。Ras/Raf/MEK/ERK通路可以诱导与细胞增殖和细胞周期阻滞相关的事件。所选择的特定过程可能取决于Ras激活的强度和特定的Raf基因。该通路还通过调节Bad和Bcl-2等凋亡分子的活性来维持细胞存活。本文将讨论Ras/Raf/MEK/ERK通路的调控及其如何调节细胞周期进程和细胞存活。
The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle progression and apoptosis in diverse types of cells. Mutations in this pathway are often observed in transformed cell lines and frequently linked with human cancers. The Ras/Raf/MEK/ERK pathway can induce events both associated with cell proliferation and cell cycle arrest. The particular course chosen may depend on the strength and the particular Raf gene activated by Ras. This pathway also is involved in maintaining cell survival by modulating the activity of apoptotic molecules including Bad and Bcl-2. This review will discuss the regulation of the Ras/Raf/MEK/ERK pathway and how it modulates cell cycle progression and cell survival.