The differential role of androgens in early human sex development.
The differential role of androgens in early human sex development.
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雄激素在早期人性发展中的差异作用。
DOI：
10.1186/1741-7015-11-152
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发表时间：
2013-06-24
期刊：
影响因子：
9.3
通讯作者：
Hiort O
中科院分区：
文献类型：
--
作者：
Hiort O
人类的性发育仅在分子水平上得到部分了解。它依赖于主要由男性和女性之间的性染色体差异引起的遗传控制。这导致性腺的发育，随后明显表型的分化由激素作用控制。性类固醇可能会产生永久性和暂时性的影响。它们通过下游基因的遗传控制来诱导表型永久性变化的组织特征。在这一点上，雄激素是男性内生殖器和外生殖器以及其他性器官和一般身体成分分化的关键元素，通过单一雄激素受体发挥作用。雄激素受体是调节各个靶基因的DNA转录的核转录因子，从而以严格的方式驱动发育和生长。雄激素作用的特异性似乎是一个严格受时间控制的过程，雄激素受体与不同的代谢物和一系列调节细胞反应的辅助因子协同作用，从而永久改变任何给定个体的表型。对于每个由雄激素编程的细胞，必须提出一个特定的“雄激素反应指数”。
Sexual development in humans is only partly understood at the molecular level. It is dependent on genetic control primarily induced by the sex chromosomal differences between males and females. This leads to the development of the gonads, whereby afterwards the differentiation of the apparent phenotype is controlled by hormone action. Sex steroids may exert permanent and temporary effects. Their organizational features of inducing permanent changes in phenotype occur through genetic control of downstream genes. In this, androgens are the key elements for the differentiation of male internal and external genitalia as well as other sexual organs and general body composition, acting through a single androgen receptor. The androgen receptor is a nuclear transcription factor modulating DNA transcription of respective target genes and thereby driving development and growth in a stringent manner. The specificity of androgen action seems to be a strictly time-controlled process with the androgen receptor acting in concert with different metabolites and an array of cofactors modulating the cellular response and thereby permanently altering the phenotype of any given individual. For every cell programmed by androgens, a specific ‘androgen response index’ must be proposed.
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影响因子：
4.4
作者：
Holterhus PM;Deppe U;Werner R;Richter-Unruh A;Bebermeier JH;Wünsch L;Krege S;Schweikert HU;Demeter J;Riepe F;Hiort O;Brooks JD
通讯作者：
Brooks JD
影响因子：
4.7
作者：
Bebermeier, Jan-Hendrik;Brooks, James D.;Holterhus, Paul-Martin
通讯作者：
Holterhus, Paul-Martin
影响因子：
5.8
作者：
Kamrath, Clemens;Hochberg, Ze'ev;Wudy, Stefan A.
通讯作者：
Wudy, Stefan A.
DOI：
10.1016/s0960-0760(00)00174-6
发表时间：
2000-12-31
影响因子：
4.1
作者：
Hellwinkel, OJC;Bassler, J;Hiort, O
通讯作者：
Hiort, O
影响因子：
4.7
作者：
Hoppe, U.;Holterhus, P. -M.;Hiort, O.
通讯作者：
Hiort, O.