Alpha-2 adrenoceptor mediated paradoxical (REM) sleep inhibition in the cat
Alpha-2 adrenoceptor mediated paradoxical (REM) sleep inhibition in the cat
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DOI：
10.1097/00001756-199907130-00036
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发表时间：
1999-07-13
期刊：
影响因子：
1.7
通讯作者：
Sakai, K
中科院分区：
文献类型：
--
作者：
Crochet, S;Sakai, K
使用在体内微透析输注，我们研究了肾上腺素受体亚型牵连在异相睡眠（PS）的产生在猫。肾上腺素和去甲肾上腺素抑制PS和诱导PS无张力时，应用于尾侧围蓝斑-α（围LC α）的mediodorsal脑桥被盖。这种作用被α 2-选择性肾上腺素受体激动剂可乐定模拟，而α 1和β激动剂无效。去甲肾上腺素效应可被α（2）-选择性拮抗剂萝芙木碱或RX 821002拮抗，但不能被α（1）或β（1）拮抗剂拮抗。此外，可乐定完全阻断了卡巴胆碱的PS诱导作用，应用于围LC α。目前的数据表明，α（2）肾上腺素受体位于尾侧围LC α在PS生成的抑制机制中发挥关键作用。NeuroReport 10：2199-2204（C）1999 Lippincott威廉姆斯和威尔金斯。
USING in vivo microdialysis infusion, we have studied the adrenoceptor subtypes implicated in paradoxical sleep (PS) generation in the cat. Both epinephrine and norepinephrine inhibited PS and induced PS without atonia when applied to the caudal peri-locus coeruleus-alpha (peri-LC alpha) of the mediodorsal pontine tegmentum. This effect was mimicked by clonidine, an alpha(2)-selective adrenoceptor agonist, while alpha(1) and beta agonists were ineffective. The norepinephrine effect was antagonized by co-application of the alpha(2)-selective antagonists, rauwolscine or RX 821002, but not by alpha(1) or beta(1) antagonists. In addition, clonidine completely blocked the PS-inducing effect of carbachol, applied to the peri-LC alpha. The present data indicate that alpha(2) adrenoceptors located in the caudal peri-LC alpha play a critical role in inhibitory mechanisms of PS generation. NeuroReport 10:2199-2204 (C) 1999 Lippincott Williams & Wilkins.