Zanamivir prophylaxis: An effective strategy for the prevention of influenza types A and B within households
Zanamivir prophylaxis: An effective strategy for the prevention of influenza types A and B within households
复制标题
DOI：
10.1086/345722
复制
发表时间：
2002-12-01
影响因子：
6.4
通讯作者：
Kerr, C
中科院分区：
文献类型：
--
作者：
Monto, AS;Pichichero, ME;Kerr, C
进行了一项吸入扎那米韦预防家庭流感的双盲、随机研究。一旦发现疑似流感病例（指示患者），就开始治疗所有其他大于或等于5岁的家庭成员（接触者）。接触者接受10 mg扎那米韦或安慰剂吸入，每天一次，持续10天。索引患者仅接受缓解药物治疗。总共有487个家庭（242个安慰剂家庭和245个扎那米韦家庭）被纳入研究，1291个接触者被随机分配接受预防治疗。4%的扎那米韦家庭对19%的安慰剂家庭（P
A double-blind, randomized study of inhaled zanamivir for the prevention of influenza in families was conducted. Once a person with a suspected case of influenza was identified (index patient), treatment of all other household members (contacts) greater than or equal to5 years old was initiated. Contacts received either 10 mg zanamivir or placebo inhaled once daily for 10 days. Index patients received relief medication only. In total, 487 households (242 placebo and 245 zanamivir) were enrolled, with 1291 contacts randomly assigned to receive prophylaxis. Four percent of zanamivir versus 19% of placebo households (P