Generation of an induced pluripotent stem cell line (SYSUi005-A) from a patient with hypertrophic cardiomyopathy
Generation of an induced pluripotent stem cell line (SYSUi005-A) from a patient with hypertrophic cardiomyopathy
复制标题
从肥厚型心肌病患者中产生诱导多能干细胞系 (SYSUi005-A)
DOI：
10.1016/j.scr.2021.102626
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发表时间：
2021
影响因子：
1.2
通讯作者：
Qiuling Xiang
中科院分区：
文献类型：
--
作者：
Chi Zhang;Jian Shi;Zhen Zhang;Qianqian Zhao;Manting Xie;Ying Chen;Qiuling Xiang
Hypertrophic cardiomyopathy (HCM) is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. Here, we reprogrammed peripheral blood mononuclear cells (PBMCs) isolated from peripheral blood of a patient who suffered from hypertrophic cardiomyopathy, into pluripotent stem cells (iPSC) (SYSUi005-A) using Sendai-virus. The established hiPSC line displayed a normal 46XY karyotype, showing strong expression of pluripotency markers and differentiation potential. This cell line may represent a valuable tool for investigating the pathogenesis and therapeutic strategies of HCM.
