Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis.
Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis.
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HBsAg 阴性慢性活动性肝炎肝膜自身抗体的检测。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
W. Arnold
中科院分区：
文献类型：
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作者：
U. Hopf;K. Meyer zum Büschenfelde;W. Arnold
对慢性活动性肝炎和其他肝病患者肝细胞膜抗原的体液免疫的研究表明，肝细胞膜上IgG的免疫荧光模式有两种不同。HBsAg阴性肝炎呈线性模式，但HBsAg阳性病例和一些迁延性急性B肝炎呈颗粒状模式。在IgG与肝细胞结合的患者中，观察到实质肝细胞持续坏死。相反，在慢性活动性肝炎缓解期、无HBsAg的急性病毒性肝炎和慢性迁延性肝炎、“健康”HBsAg携带者和脂肪肝或酒精性肝硬化患者中发现了无结合IgG的肝细胞。血清中的肝膜自身抗体，通过固定在离体兔肝细胞膜上证明，只能在IgG浓度升高的HBeAg阴性慢性活动性肝炎中证明。结果支持慢性活动性肝炎存在不同的致病类型，即所谓的自身免疫型和乙型肝炎病毒诱导型。
Investigation of humoral immunity against hepatocellular membrane antigens in patients with chronic active hepatitis and other liver diseases showed two different immunofluorescence patterns of IgG on hepatocyte membranes. A linear pattern was seen in HBsAg-negative hepatitis, but HBsAg-positive cases and some of protracted, acute hepatitis B had a granular pattern. In patients with IgG bound to hepatocytes, continuing necrosis of parenchymal liver cells was seen. Conversely, hepatocytes without bound IgG were found in cases of chronic active hepatitis in remission, acute viral hepatitis without HBsAg and chronic persistent hepatitis, in "healthy" HBsAg-carriers and in patients with fatty liver or alcoholic cirrhosis. A liver-membrane autoantibody in serum, proved by fixation on membranes of isolated rabbit hepatocytes, could be demonstrated only in HBsAg-negative chronic active hepatitis with elevated IgG-concentrations. The results support the existence of different pathogenetic types of chronic active hepatitis, a so-called autoimmune type and a hepatitis virus-B-induced type.