Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance.
Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance.
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DOI：
10.1038/srep10949
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发表时间：
2015-06-16
影响因子：
4.6
通讯作者：
Elkum N
中科院分区：
文献类型：
--
作者：
Abu-Farha M;Abubaker J;Al-Khairi I;Cherian P;Noronha F;Hu FB;Behbehani K;Elkum N
Betatrophin/ANGPTL8是一种新发现的在肝脏和脂肪组织中产生的激素，已被证明是胰岛素抵抗的结果，并调节脂质代谢。人们对betatrophin水平及其与T2D和代谢危险因素的关系知之甚少。采用ELISA法测定了1603例（1047例非糖尿病患者和556例T2D患者）血浆betatrophin水平，并研究了其与非糖尿病和T2D患者代谢危险因素的关系。我们的数据显示，非糖尿病患者（731.3 (59.5-10625.0)pg/ml）和T2D患者(1710.5（197.4-12361.1）之间betatrophin水平有显著差异，p < 0.001。在非糖尿病受试者中，Betatrophin与年龄、BMI、腰臀比、FBG、HbA1C、HOMA-IR、TG呈正相关。然而，在t2dm患者中，与BMI、FBG、HbA1C或HOMA-IR没有关联。T2D患者TC、LDL与betatrophin呈负相关。多因素分析显示，betatrophin含量最高的受试者患T2D的几率较高（奇比[OR] = 6.15, 95%可信区间[CI] =(3.15 ~ 12.01)）。我们的数据显示，在非糖尿病受试者中，betatrophin与FBG和胰岛素抵抗之间存在强烈的正相关。然而，在T2D受试者中，与FBG和胰岛素抵抗的相关性减弱。
Betatrophin/ANGPTL8 is a newly identified hormone produced in liver and adipose tissue that has been shown to be induced as a result of insulin resistance and regulates lipid metabolism. Little is known about betatrophin level in humans and its association with T2D and metabolic risk factors. Plasma level of betatrophin was measured by ELISA in 1603 subjects: 1047 non-diabetic and 556 T2D subjects and its associations with metabolic risk factors in both non-diabetic and T2D were also studied. Our data show a significant difference in betatrophin levels between non-diabetic (731.3 (59.5–10625.0) pg/ml) and T2D (1710.5 (197.4–12361.1) p < 0.001. Betatrophin was positively correlated with age, BMI, waist/hip ratio, FBG, HbA1C, HOMA-IR and TG in the non-diabetic subjects. However, no association was observed with BMI, FBG, HbA1C or HOMA-IR in T2D subjects. TC and LDL showed negative association with betatrophin in T2D subjects. Multivariate analysis showed that subjects in the highest tertile of betatrophin had higher odds of having T2D (odd ratio [OR] = 6.15, 95% confidence interval [CI] = (3.15 – 12.01). Our data show strong positive associations between betatrophin and FBG and insulin resistance in non-diabetic subjects. However, correlations with FBG and insulin resistance were diminished in T2D subjects.