The Assessment of Cough in a Sarcoidosis Clinic Using a Validated instrument and a Visual Analog Scale
The Assessment of Cough in a Sarcoidosis Clinic Using a Validated instrument and a Visual Analog Scale
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DOI：
10.1007/s00408-017-0040-3
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发表时间：
2017-10-01
期刊：
影响因子：
5
通讯作者：
Yucel, Recai M.
中科院分区：
文献类型：
--
作者：
Judson, Marc A.;Chopra, Amit;Yucel, Recai M.
目的咳嗽是肺结节病的常见症状。方法采用莱斯特咳嗽问卷(LCQ)和咳嗽视觉模拟评定量表(VAS)对连续入院的患者进行问卷调查。收集了临床和人口学数据。结果355例患者在874次就诊中完成了LCQ和VAS。根据Lcq均分(16.5+/-2.6vs.17.8+/-3.0p<；0.001)和视觉模拟均分(3.8士/-3.0vs.2.0+/-2.6p<；0.0001)，黑人的咳嗽明显比白人严重。女性咳嗽比男性更严重，这是视觉模拟评分的平均值(2.7vs.2.2+/-2.7vs.2.2+/-2.7p=0.002)，也是学习质量的一个平均领域(学习质量-社会-平均5.4vs.5.2+/-1.0，p=0.03)，但不是总的学习质量平均得分。咳嗽在吸烟状态、年龄或肺活量参数(FVC预测百分比、FEV1预测百分比、FEV1/FVC)方面均无显著差异。在多变量线性回归分析中，黑人的咳嗽明显比白人严重，肺结节病的咳嗽明显比非肺结节病严重，仅就VAS而言，女性比男性严重，而在肺活量参数、分级或年龄方面没有。结论在一个大型大学门诊结节病患者队列中，黑人的咳嗽比白人更严重。咳嗽在年龄、肺活量测量、加重阶段或吸烟状况方面没有统计学上的显著差异。LCQ与咳嗽的视觉模拟评分有很强的相关性。
Purpose Cough is a common symptom of pulmonary sarcoidosis. We analyzed the severity of cough and factors associated with cough in a university sarcoidosis clinic cohort.Methods Consecutive patients completed the Leicester Cough Questionnaire (LCQ) and a cough visual analog scale (VAS). Clinical and demographic data were collected. Means of the LCQ were analyzed in patients who had multiple visits in terms of constant variables (e.g., race, sex).Results 355 patients completed the LCQ and VAS at 874 visits. Cough was significantly worse in blacks than whites as determined by the LCQ-mean (16.5 +/- 2.6 vs. 17.8 +/- 3.0, p < 0.001) and VAS-mean (3.8 +/- 3.0 vs. 2.0 +/- 2.6, p < 0.0001). Cough was worse in women than men as measured by the VAS-mean (2.7 +/- 2.9 vs. 2.2 +/- 2.7, p = 0.002), one of the LCQ-mean domains (LCQ-Social-mean 5.4 +/- 0.9 vs. 5.2 +/- 1.0, p = 0.03), but not the total LCQ-mean score. Cough was not significantly different by either measure in terms of smoking status, age, or spirometric parameter (FVC % predicted, FEV1 % predicted, FEV1/FVC). In a multivariable linear regression analysis, cough was significantly worse in blacks than whites and in pulmonary sarcoidosis than non-pulmonary sarcoidosis with both cough measures, in women than men for the VAS only, and not for spirometric parameters, Scadding stage, or age. The LCQ and VAS were strongly correlated.Conclusions In a large university outpatient sarcoidosis cohort, cough was worse in blacks than whites. Cough was not statistically significantly different in terms of age, spirometric measures, Scadding stage, or smoking status. The LCQ correlated strongly with a visual analog scale for cough.