Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.
Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0193857
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Ma F
中科院分区：
文献类型：
--
作者：
Ma QQ;Fan XD;Li T;Hao YY;Ma F
低钠血症与心力衰竭、肝硬变和中风有关，但血清钠水平对急性冠脉综合征患者的预后价值仍不清楚。因此，我们进行了一项系统的综述和荟萃分析，以评估低钠血症对急性冠脉综合征患者不良事件的预后价值。我们系统地检索PubMed、Embase和Cochrane图书馆，寻找研究低钠血症对急性冠脉综合征患者预后价值的文献。我们的主要终点是短期和长期的全因死亡率和心力衰竭。在369项已确定的研究中，有20项研究纳入了我们的分析。与正常钠血症相比，低钠血症与30天内(RR：2.18；95%CI：1.96~2.42)和随访期间(HR：1.74；95%CI：1.5 6~1.942)全因死亡风险增加显著相关。对于短期和长期心力衰竭的第二终点，低钠血症患者的合并效应大小分别为1.72(95%CI：1.38-2.14)和1.69(95%CI：1.12-2.55)。总之，低钠血症对急性冠脉综合征患者的短期和长期不良事件有显著的预后价值，动态监测血钠水平可能有助于医生识别高危急性冠脉综合征患者，并对风险进行分层，以便进行最佳处理。
Hyponatremia is relevant to heart failure, liver cirrhosis and stroke, but the prognostic value of serum sodium levels in patients with acute coronary syndrome are still unclear. So we did a systematic review and meta-analysis to assess the prognostic value of hyponatremia on adverse events in patients after ACS. We systematically searched PubMed, Embase and Cochrane Library to find literatures which studied the prognostic value of hyponatremia in patients with ACS. Our main endpoints were the all-cause mortality and heart failure in the short- and long-term. Of 369 identified studies, 20 studies were included in our analysis. Compared with the normal natrium, hyponatremia was significantly associated with the increased risks of all-cause mortality within 30 days (RR: 2.18; 95%CI: 1.96–2.42) and during the follow-ups (HR: 1.74; 95%CI: 1.56–1.942). For the second endpoint of short- and long-term heart failure, the pooled effect sizes in hyponatremia patients were 1.72(95%CI: 1.38–2.14) and 1.69(95%CI: 1.12–2.55) respectively. In conclusion, hyponatremia has a significant prognostic value for short- and long-term adverse event in patients after ACS, the dynamic monitoring of serum sodium levels may could help physicians to identify high risk ACS patients and to stratify risk for optimal management.
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影响因子：
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