Atopic disease and exhaled nitric oxide in an unselected population of young adults
Atopic disease and exhaled nitric oxide in an unselected population of young adults
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DOI：
10.1016/s1081-1206(10)60406-1
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发表时间：
2008-01-01
影响因子：
5.9
通讯作者：
van der Ent, Cornelis K.
中科院分区：
文献类型：
--
作者：
van Asch, Charlotte J. J.;Balemans, Walter A. F.;van der Ent, Cornelis K.
背景资料：几项研究报告了特应性患者，特别是哮喘患者的呼出气一氧化氮（FeNO）分数水平升高，表明FeNO是支气管炎症的标志物。然而，不同的特应性实体（湿疹，过敏性鼻炎和哮喘）对FeNO的独立影响从未在一般population.Objective：研究的影响，基于免疫球蛋白的特应性疾病和IgE和肺功能测量FeNO水平的诊断。研究方法：这项研究是对1982年9月1日至1983年8月31日期间在荷兰奈梅亨出生的1,328名儿童的中耳炎随访的一部分。在出生队列，哮喘，过敏性鼻炎，湿疹的发病率进行了测定，并离线FeNO，肺功能测定，IgE测量进行了21 years.Results：FeNO测量成功地进行了361名参与者。有湿疹的患者与无湿疹的患者相比，（23.6 vs 18.0 ppb; P <0.0001），有与无过敏性鼻炎（20.7 vs 17.8 ppb; P = 0.0001），有与无特应性哮喘的患者（23.3 vs 18.1 ppb; P = 0.02），但在哮喘患者vs非哮喘患者中则无此差异（20.8 vs 18.3 ppb; P = 0.24）。在该人群样本中，过敏性鼻炎、吸烟、性别和特应性过敏似乎与log FeNO独立相关，而（特应性）哮喘则不相关。没有影响FeNO水平观察肺功能parameters.Conclusion：湿疹，过敏性鼻炎，特应性状态都独立与FeNO水平升高，而（特应性）哮喘没有。这一发现意味着未来对FeNO在哮喘中作用的研究应考虑肺外特应性疾病的影响。
Background: Several studies have reported elevated levels of fractional exhaled nitric oxide (FeNO) in atopic patients, particularly in asthmatic patients, suggesting that FeNO is a marker of bronchial inflammation. However, the independent influence of different atopic entities (eczema, allergic rhinitis, and asthma) on FeNO has never been studied in the general population.Objective: To study the influence of a questionnaire-based diagnosis of atopic diseases and IgE and lung function measurements on FeNO levels. Methods: This study was part of a follow-up on otitis media of a birth cohort of 1,328 children born in Nijmegen, the Netherlands, between September 1, 1982, and August 31, 1983. Within the birth cohort, the incidence of asthma, allergic rhinitis, and eczema was determined, and off-line FeNO, spirometry, and IgE measurements were performed at the age of 21 years.Results: FeNO measurements were successfully performed in 361 participants. Median FeNO levels were significantly higher in those with vs without eczema (23.6 vs 18.0 ppb; P < .0001), those with vs without allergic rhinitis (20.7 vs 17.8 ppb; P =.0001), and those with vs without atopic asthma (23.3 vs 18.1 ppb; P =.02) but not in those with vs without asthma (20.8 vs 18.3 ppb; P =.24). Eczema, allergic rhinitis, smoking, sex, and atopic sensitization appeared to be independently associated with log FeNO in this population sample, whereas (atopic) asthma was not. No effect on FeNO levels was observed for lung function parameters.Conclusion: Eczema, allergic rhinitis, and atopic status were all independently associated with elevated FeNO levels, whereas (atopic) asthma was not. This finding implies that future studies into the role of FeNO in asthma should consider the influence of atopic disease outside the lungs.