Dynamics of copper regulation in a marine clam Sinonovacula constricta at the organ level: Insight from a physiologically based pharmacokinetic model.
Dynamics of copper regulation in a marine clam Sinonovacula constricta at the organ level: Insight from a physiologically based pharmacokinetic model.
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DOI：
10.1016/j.envpol.2023.122421
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发表时间：
2023-08
影响因子：
8.9
通讯作者：
Yizhou Ke;Wen Wang
中科院分区：
文献类型：
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作者：
Yizhou Ke;Wen Wang
铜是河口常见的污染物，在世界范围内受到广泛关注。为了深入了解河口沙棘对水中铜的吸收、组织分布、储存、代谢和排泄的生理机制，我们建立了基于长期铜暴露和两种暴露处理的生理学药代动力学模型。其组织分为四部分：血液、消化腺、鳃和其他组织。结果表明，水中铜主要通过鳃和消化腺进入和交换，而消化腺和其他组织是铜的主要储存场所。Gills OFS.在两种暴露处理下，金龟子都能维持其铜含量。此外，鳃对水中的铜有很强的脱除能力，从鳃到水的转移速率常数为1.73d−1，而从血液到鳃的转移速率常数为0.0131 d−1，限制了其从血液中的转移。这些结果突显了鳃在调节铜水平中的关键作用。收缩以及解毒和维持金属动态平衡。从水中摄取铜的速率常数与消化腺相似(0.294比0.364，L−1D−1)，因此进入消化道的水被认为是双壳类水中铜吸收的另一条途径。血液中的大量铜被转移到消化腺。这两个因素解释了文蛤消化腺中铜的积累量高于其他组织的原因。这项研究的结果加深了我们对海洋双壳类体内平衡调节和运输机制的理解。
Copper (Cu) is a common pollutant in estuaries and has received considerable attention worldwide. To gain an insight into the physiological mechanisms of waterborne Cu absorption, tissue distribution, storage, metabolism, and excretion in an estuarine razor clamSinonovacula constricta, we developed a physiologically-based pharmacokinetic model based on prolonged Cu exposure with two exposure treatments. The tissues ofS.constrictawere divided into four parts: blood, digestive gland, gill, and other tissues. Our results showed that the waterborne Cu entered and exchanged with the gills and digestive gland, whereas digestive gland and other tissues were the main storage sites for Cu. Gills ofS. constrictawere able to maintain their Cu concentrations under both exposure treatments. Additionally, the gills exhibited a remarkable ability to remove Cu from water, with a transfer rate constant of 1.73 d−1from the gills to water, while restricting its transfer from the blood with a transfer rate constant of 0.0131 d−1from blood to gills. These results highlighted the crucial role of gills in regulating Cu levels inS. constrictaas well as the detoxification and maintenance of metal homeostasis. Cu uptake rate constant in gill from waterborne was similar to that of digestive gland (0.294 vs. 0.364 L g−1d−1), thus water entering the digestive tract was considered as another route of waterborne Cu absorption in bivalves. A significant amount of Cu in the blood was transferred to the digestive glands. These two factors explained the relatively higher Cu accumulation in the digestive glands than in other tissues in clams. The findings of this study enhanced our understanding of the homeostatic regulation and transportation mechanisms in marine bivalves.