Expression of the inhibitor of apoptosis protein survivin in benign meningiomas
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas
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DOI：
10.1016/s0304-3835(02)00741-3
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发表时间：
2003-04-25
期刊：
影响因子：
9.7
通讯作者：
Smith, DR
中科院分区：
文献类型：
--
作者：
Das, A;Tan, WL;Smith, DR
Survivin 是最近鉴定的一种凋亡蛋白抑制剂，该蛋白与多种实体器官癌的发病机制有关。本研究试图描述 90 个良性脑膜瘤中 survivin 的表达，以及参与细胞凋亡过程的其他基因（即 bax 和 bcl2）的表达模式。 94% (85/90) 的样本中发现存活蛋白表达，并且与 bax 或 bcl2 的表达或临床病理因素不相关。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the apoptotic process, namely bax and bcl2. Survivin expression was noted in 94% (85/90) of samples and was not correlated with the expression of either bax or bcl2 or with clinicopathological factors. (C) 2003 Elsevier Science Ltd. All rights reserved.