A consumer's guide to meta-analysis.
A consumer's guide to meta-analysis.
复制标题
元分析消费者指南。
DOI：
10.1002/art.1790100309
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
LaValley,M
中科院分区：
文献类型：
--
作者：
LaValley,M
荟萃分析是一种将先前研究的结果统计汇总为单一定量分析的分析，一位支持者将其描述为为治疗效果提供了最高水平的证据(1)。这种类型的分析有广泛的文献(2-6)，并已成为医学研究中常用的工具。它经常被用来评估临床试验的集合zyxwvutsrqponml(7，8)，但也被用于汇集流行病学研究zyxwvutsrqponmlkjih(9)。本文的目的是简要列出在构建可靠的荟萃分析时应考虑的问题。这些问题是如何解决的，需要在这种综合分析的报告中加以说明，我将讨论这种报告应该包括哪些内容。这是为了帮助读者对已发表的元分析进行批判性的评估，并提供如何报告自己的元分析的指导方针。文中将对这些研究中涉及的统计学问题进行简要解释，但希望进行自己的元分析的读者应参考参考文献中列出的原始材料，以全面解释元分析的技术、限制和解释。荟萃分析中使用的技术是作为一种系统的方法发展起来的，这些方法结合了以前报道的、往往是相互矛盾的某一领域研究的结果，以达到综合。因此，元分析的目的是提供一个更客观和可重现的版本，由该领域的专家对某一主题领域的传统总结和审查，用IM取代专家的经验和意见。
Meta-analysis, an analysis that statistically pools the results from previous studies into a single quantitative analysis, has been described by one proponent as providing the very highest level of evidence for treatment efficacy (1). This type of analysis has an extensive literature (2-6) and has become a commonly employed tool in medical research. It is often used to evaluate collections of clinical trials zyxwvutsrqponml (7, 8), but has also been used to pool epidemiologic studies zyxwvutsrqponmlkjih (9). The aim of this article is to provide a brief listing of the issues that should be considered in the construction of a solid meta-analysis. How these issues were addressed needs to be featured in the report from such a meta-analysis, and I will discuss what should be included in such a report. This is intended to help readers in critical evaluation of published meta-analyses, as well as provide guidelines on how to report a meta-analysis of one’s own. Brief explanations of the statistical issues involved in the combination of studies will be given, but readers who wish to perform their own meta-analyses should consult the source materials listed in the references for full explanations of the techniques, limitations, and interpretations of meta-analysis. The techniques used in meta-analysis were developed as systematic methods of combining the results of previously reported, and often contradictory, studies in an area in order to reach a synthesis. As such, metaanalysis is intended to provide a more objective and reproducible version of the traditional summary and review of a subject area by an expert in the field, with the expert’s experience and opinions replaced by im-