Basal sympathetic activity to the microcirculation in tetraplegic man revealed by wavelet transform of laser Doppler flowmetry
Basal sympathetic activity to the microcirculation in tetraplegic man revealed by wavelet transform of laser Doppler flowmetry
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DOI：
10.1016/j.mvr.2011.01.005
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发表时间：
2011-05-01
影响因子：
3.1
通讯作者：
Tuckman, J.
中科院分区：
文献类型：
--
作者：
Bernjak, A.;Deitrick, G. A.;Tuckman, J.
背景资料：1984/86年发表的神经电图结果显示，四肢瘫痪患者的肌肉和皮肤只有罕见的交感神经活动（SNA），这一结果仍然被接受。本研究通过不同的方法试图证实或否认这些findings.Methods和结果：基础SNA的影响，足部和小腿的微循环在10个完整的（AIS A）创伤性四肢瘫痪和10个健康的年龄相匹配的主题进行了评价，通过小波变换的激光多普勒血流仪（LDF）记录。结果清楚地表明，有显着的基础SNA从分散的脊髓四肢瘫痪。此外，小波分析允许的微循环除了SNA的其他影响的研究。总的来说，与对照组相比，四肢瘫痪患者血流中低频振荡的功率降低;内皮细胞引起的血管舒张较少，而SNA和固有血管平滑肌引起的血管收缩程度较小。然而，高频，特别是心脏功率更大。后者提出了一个明显的重要因素，为保存的血流在微循环。结论：它建议，基础SNA皮肤微循环发生在完全四肢瘫痪，和循环去甲肾上腺素的显着水平，由其他人报告表明，这也是如此，在身体的其他部位。这可能解释了在这种情况下通常没有严重的，失能的，自主神经功能障碍。爱思唯尔公司出版
Background: The 1984/86 published neurogram results showing only rare sympathetic nerve activity (SNA) to the muscles and skin in tetraplegia are still accepted. The present study by a different method attempted to confirm or deny those findings.Methods and results: The effect of basal SNA to the microcirculation of the feet and calf in 10 complete (AIS A) traumatic tetraplegic and 10 healthy age matched subjects were evaluated by wavelet transform of laser Doppler flowmetry (LDF) recordings. The results clearly indicated there is significant basal SNA from the decentralized spinal cord in tetraplegia. In addition, wavelet analysis allowed a study of other influences on the microcirculation besides SNA. Collectively, in tetraplegia compared with controls, the powers of the low frequency oscillations in blood flow were reduced; in that the endothelium caused less vasodilatation while the SNA and intrinsic vascular smooth muscles induced smaller degrees of vasoconstriction. However, the high frequency and especially the cardiac powers were greater. The latter presenting an obvious important factor for the preservation of blood flow in the microcirculation.Conclusions: It is suggested that basal SNA to the cutaneous microcirculation occurs in complete tetraplegia, and the significant levels of circulating noradrenaline reported by others indicate this is also true in other parts of the body. This may explain the usual absence of severe, incapacitating, autonomic deficiency in this condition. Published by Elsevier Inc.