Metabolic depression during aestivation in Cyclorana alboguttata
Metabolic depression during aestivation in Cyclorana alboguttata
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DOI：
10.1016/j.cbpa.2009.09.001
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发表时间：
2009-12-01
影响因子：
2.3
通讯作者：
Franklin, Craig E.
中科院分区：
文献类型：
--
作者：
Kayes, Sara M.;Cramp, Rebecca L.;Franklin, Craig E.
绿色条纹穴居蛙，Cyclorana alboguttata，平均每年有9到10个月的夏眠。最近，C alboguttata一直是许多研究的重点，关于涉及夏眠的生理过程，但我们的理解这种青蛙的代谢抑制的能力仍然有限。本研究的目的是扩大我们目前的知识，代谢抑制在夏眠期间的白纹伊蚊。C alboguttata减少整个动物的代谢82%，在5周内的夏眠。夏眠对特定质量的体外组织代谢率（VO 2）的影响在各个器官之间存在差异，肌肉和肝脏切片显示代谢显着降低;肾脏VO 2升高，小肠组织切片的VO 2没有变化。器官大小也受到夏眠的影响，除了腓肠肌外，所有组织的质量都显着减少。这些器官大小的减少，结合组织切片的质量特异性VO 2的变化，导致夏眠动物进一步节省能量。这项研究表明，C alboguttata是能够选择性地下调或上调个别组织，利用代谢率和形态的变化。这种策略可以在夏眠期间最大限度地节省能量，而不会损害器官功能和唤醒时的生存。(C)2009 Elsevier Inc. All rights reserved.
The green striped burrowing frog, Cyclorana alboguttata, spends, on average, nine to ten months of every year in aestivation. Recently, C alboguttata has been the focus of much investigation regarding the physiological processes involved in aestivation, yet our understanding of this frog's capacity to metabolically depress remains limited. This study aimed to extend our current knowledge of metabolic depression during aestivation in C alboguttata. C alboguttata reduced whole animal metabolism by 82% within 5 weeks of aestivation. The effects of aestivation on mass specific in vitro tissue metabolic rate (VO2) varied among individual organs, with muscle and liver slices showing significant reductions in metabolism; kidney VO2 was elevated and there was no change in the VO2 of small intestine tissue slices. Organ size was also affected by aestivation, with significant reductions in the mass of all tissues, except the gastrocnemius. These reductions in organ size, combined with changes in mass specific VO2 of tissue slices, resulted in further energy savings to aestivating animals. This study shows that C alboguttata is capable of selectively down- or up-regulating individual tissues, using both changes in metabolic rate and morphology. This strategy allows maximal energy savings during aestivation without compromising organ functionality and survival at arousal. (C) 2009 Elsevier Inc. All rights reserved.