Lesions of the cholinergic nuclei in the rat basal forebrain: excitotoxins vs. an immunotoxin.
Lesions of the cholinergic nuclei in the rat basal forebrain: excitotoxins vs. an immunotoxin.
复制标题
大鼠基底前脑胆碱能核损伤：兴奋毒素与免疫毒素。
DOI：
10.1016/0024-3205(96)00184-1
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发表时间：
1996
期刊：
影响因子：
6.1
通讯作者：
Thal,LJ
中科院分区：
文献类型：
--
作者：
Waite,JJ;Thal,LJ
与心室内注射免疫毒素 IgG-皂素相比，将兴奋毒素、鹅膏蕈酸、使君子酸或 AMPA 输注到大鼠的内侧隔核、对角线带和大细胞基底核中，通过投影野、皮层和海马中的胆碱乙酰转移酶活性评估，产生的胆碱能细胞损失较少。所有兴奋毒素都会降低某些单胺的组织水平，而免疫毒素则没有发现降低。所有毒素都会在隐藏平台水迷宫中产生获得性损伤。对于兴奋性毒性损伤的大鼠，这种行为缺陷比那些给予 IgG-皂草素的大鼠稍大一些，其剂量产生与最强的兴奋性毒素 (AMPA) 相似的 ChAT 消耗。这支持了以下观点：兴奋性毒性损伤产生的一些行为效应是由于胆碱能基底前脑损伤而引起的，而另一些则是由于非胆碱能损伤引起的。
Infusion of the excitotoxins, ibotenic acid, quisqualic acid, or AMPA, into the medial septal nucleus, diagonal band, and the nucleus basalis magnocellularis of rats produced less cholinergic cell loss as assessed by choline acetyltransferase activity in the projection fields, cortex and hippocampus, than that obtainable by intraventricular administration of the immunotoxin,IgG-saporin. All excitotoxins produced reductions in tissue levels of some monoamines, while no decreases were found for the immunotoxin. All toxins produced acquisitional impairment in the hidden platform water maze. This behavioral deficit was slightly greater for the excitotoxic-lesioned rats than for those given IgG-saporin at a dose which produced ChAT depletions similar to the most potent excitotoxin (AMPA). This supports the idea that some of the behavioral effects produced by excitotoxic lesions are due to the cholinergic basal forebrain lesion and some are due to noncholinergic damage.