T-Oligos Inhibit Growth and Induce Apoptosis in Human Ovarian Cancer Cells
T-Oligos Inhibit Growth and Induce Apoptosis in Human Ovarian Cancer Cells
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DOI：
10.1089/oli.2010.0259
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发表时间：
2011-02-01
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影响因子：
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通讯作者：
Faller, Douglas V.
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文献类型：
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作者：
Sarkar, Sibaji;Faller, Douglas V.
Ovarian cancer remains a leading cause of death among women worldwide, and current treatment regimens for advanced disease are inadequate. Oligonucleotides with sequence homology to telomeres (called T-oligos) have been shown to mimic DNA damage responses in cells and induce cytotoxic effects in certain tumor cell lines. We studied the effects of 2 distinct 16 mer T-oligos in 4 human ovarian epithelial carcinoma cell lines. A T-oligo with perfect homology to the telomere overhang region demonstrated some cytotoxic activity in half of the cell lines. A G-rich T-oligo derivative showed more potency and broader cytotoxic activity in these lines than the parental T-oligo. Activation of apoptotic pathways in ovarian cancer cells by exposure to the T-oligo was demonstrated by multiple independent assays. T-oligo was shown to have additive, or more than additive, activity in combination with 2 different histone deacetylase drugs currently in clinical testing. T-oligos may therefore provide a new and tumor-targeted approach to ovarian cancers.
