Health-related quality of life in patients with primary Sjogren's syndrome: relationship with serum levels of proinflammatory cytokines
Health-related quality of life in patients with primary Sjogren's syndrome: relationship with serum levels of proinflammatory cytokines
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DOI：
10.1080/03009740902973821
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Giron-Gonzalez, J. A.
中科院分区：
文献类型：
--
作者：
Baturone, R.;Soto, M. J.;Giron-Gonzalez, J. A.
目的：30例原发性干燥综合征（pSS）进行了横断面研究，以分析与健康相关的生活质量及其与血清水平的巨噬细胞和淋巴细胞源性cytokines.Patients和方法：健康相关的生活质量进行了评估，使用36项简表健康调查（SF-36）。白细胞介素（IL）-1 β，IL-6，IL-10，肿瘤坏死因子（TNF）-α，γ-干扰素（γ-INF）的血清水平进行了分析，由一个夹心免疫分析为基础的蛋白质阵列system.Results：SF-36评估生活质量的8个尺度，以及身体综合评分（PCS）和精神综合评分（MCS），显示减少pSS患者。类似地，与健康对照组（n = 20）相比，pSS患者显示分析的五种细胞因子中的每一种的浓度显著增加。在pSS患者中，检测到血清IL-6水平与SF-36的PCS之间存在显著负相关。那些患者的IL-6浓度高于健康对照组的表现出显着较低的分数在身体疼痛和身体功能的尺寸，并在pcs.Conclusions：pSS患者表现出几个巨噬细胞和淋巴细胞衍生的细胞因子的水平增加，表明存在的免疫激活状态。这些细胞因子之一，IL-6，血清水平与这些人的生活质量差。
Objective: A cross-sectional study of 30 patients with primary Sjogren's syndrome (pSS) was performed to analyse the health-related quality of life and its relationship with serum levels of macrophage-and lymphocyte-derived cytokines.Patients and methods: Health-related quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Serum levels of interleukin (IL)-1 beta, IL-6, IL-10, tumour necrosis factor (TNF)-alpha, and gamma-interferon (gamma-INF) were analysed by a sandwich immunoassay-based protein array system.Results: Each of the eight scales of the SF-36 evaluating quality of life, as well as the physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS patients. Similarly, patients with pSS showed significantly increased concentrations of each of the five cytokines analysed, when compared with the healthy control group (n = 20). In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. Those patients with concentrations of IL-6 higher than those of the healthy controls showed a significantly lower score in the dimensions of bodily pain and physical functioning, and in the PCS.Conclusions: Patients with pSS showed increased levels of several macrophage-and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals.