P fimbriae and aerobactin as intestinal colonization factors for Escherichia coli in Pakistani infants
P fimbriae and aerobactin as intestinal colonization factors for Escherichia coli in Pakistani infants
复制标题
P菌毛和需氧菌素作为巴基斯坦婴儿大肠杆菌的肠道定植因子
DOI：
10.1017/s095026880100512x
复制
发表时间：
2001
影响因子：
4.2
通讯作者：
I. Adlerberth
中科院分区：
文献类型：
--
作者：
F. Nowrouzian;A. Wold;I. Adlerberth
从22名0-6个月大的巴基斯坦家庭分娩婴儿的直肠植物群中获得的常驻和瞬时大肠杆菌菌株之间的一系列毒力基因的携带率进行了比较。以下毒力因子的基因进行了评估，使用多重PCR：P，1型和S菌毛，三个P菌毛粘附素品种，博士血凝素，K1和K5胶囊，溶血素和需氧菌素。急诊这里检测的大肠杆菌菌株与以前从西欧宿主中获得的菌株不同，P、S和1型菌毛、K1荚膜和溶血素基因的流行率较低。然而，如先前在瑞典的一项研究中所观察到的，P菌毛、papG粘附素的II类变体和需氧菌素的基因在居民菌株中比瞬时菌株中显著更常见。结果提示，以前被认为是泌尿道感染毒力因子的P菌毛和需氧菌素可能有助于E.大肠杆菌在正常的肠道菌群。
The carriage rate of a range of virulence genes was compared between resident and transient Escherichia coli strains obtained from the rectal flora of 22 home-delivered Pakistani infants 0–6 months old. Genes for the following virulence factors were assessed using multiplex PCR: P, type 1 and S fimbriae, three P fimbrial adhesin varieties, Dr haemagglutinin, K1 and K5 capsule, haemolysin and aerobactin. The E. coli strains examined here differed from those previously obtained from hosts in Western Europe in a lower prevalence of genes for P, S and type 1 fimbriae, K1 capsule and haemolysin. Nevertheless, genes for P fimbriae, the class II variety of papG adhesin, and aerobactin were significantly more common among resident than transient strains, as previously observed in a Swedish study. The results suggest that P fimbriae and aerobactin, previously implicated as virulence factors for urinary tract infection, might contribute to persistence of E. coli in the normal intestinal microflora.