p-Terphenyl alcohols from a marine sponge-derived fungus, Aspergillus candidus OUCMDZ-1051
p-Terphenyl alcohols from a marine sponge-derived fungus, Aspergillus candidus OUCMDZ-1051
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来自海洋海绵衍生真菌 Aspergillus candidus OUCMDZ-1051 的对三联苯醇
DOI：
10.1007/s42995-020-00039-x
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发表时间：
2020-08-01
影响因子：
5.7
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Wang, Dongyang;Qu, Peng;Zhu, Weiming
为了从海洋生物中发现新的结构和生物活性的化合物，我们研究了西沙群岛海绵(XS-3)伴生的海洋真菌的次生代谢产物。因此，从海绵来源的真菌AspergillusorcidusOUCMDZ-1051中分离和鉴定了一种新的对三苯醇-4-O-甲基假丝酵母A(1)和9个已知类似物(2-10)。通过分析波谱数据，特别是一维和二维核磁共振，确定了化合物的结构。新化合物1对人肝癌细胞株MDA-MB-468、BT474和A431的生长有选择性抑制作用，其IC50值分别为1.84、6.05和0.98mU·mol/L。化合物1对大肠埃希菌也具有选择性抗菌活性，其MIC值为27.3mU/L。结果表明，4-O-甲基假丝酵母素A(1)可能成为治疗三阴性乳腺癌、浸润性导管癌和表皮样癌新药的先导化合物。抗菌代谢产物也证明了海绵相关微生物对其进行化学防御的线索。
In order to discover structurally new and bioactive compounds from marine life, we studied the secondary metabolites of the marine-derived fungi associated with a marine sponge (XS-3) from the Xisha islands. As a result, 4-O-methylcandidusin A (1), a new p-terphenyl alcohol, along with nine known analogs (2-10), were isolated and identified from the marine sponge-derived fungus Aspergillus candidus OUCMDZ-1051. The structures of these compounds were determined by analyzing spectroscopic data, especially 1D and 2D NMR. The new compound 1 selectively inhibited the growth of the MDA-MB-468, BT474 and A431 human cancer cell lines with the IC50 values of 1.84, 6.05 and 0.98 mu mol/L, respectively. Compound 1 also displayed a selective antimicrobial activity against Escherichia coli with an MIC value of 27.3 mu mol/L. The results indicated 4-O-methylcandidusin A (1) as a potential lead in the new drug discovery for triple negative breast cancer, invasive ductal breast cancer and epidermoid cancer. The antimicrobial metabolites also evidenced a clue for chemical defense of sponges by their associated microorganisms.