Corticosteroid-binding globulin during inflammation and burn injury: Nutritional modulation and clinical implications
Corticosteroid-binding globulin during inflammation and burn injury: Nutritional modulation and clinical implications
复制标题
DOI：
10.1159/000184796
复制
发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Garrel, DR
中科院分区：
文献类型：
--
作者：
Garrel, DR
皮质类固醇结合球蛋白（Corticosteroid-binding globulin，CGB）是哺乳动物体内糖皮质激素的主要载体。除妊娠期外，血清CBG几乎无生理变化。实验性炎症和烧伤可降低大鼠的血清CBG，虽然这种作用的机制尚不清楚，但体外实验表明白细胞介素-6可能参与其中。在严重烧伤病人中，我们发现CBG在伤后数小时内明显下降。这种下降持续约2周，并伴随着血清皮质醇的游离分数的增加。此外，血清CBG对这些患者的饮食控制有反应，低脂喂养导致血清CBG浓度较高，血清游离皮质醇值较低。这一发现表明，在严重的压力下，CBG可能在调节到达免疫系统和伤口等靶组织的皮质醇量方面很重要。
Corticosteroid-binding globulin (CGB) is the main carrier of glucocorticoids in mammals. Serum CBG shows little physiological variation with the exception of pregnancy. Experimental inflammation and burn injury decrease serum CBG in rats and while the mechanism of this effect is unknown, in vitro experiments suggest that interleukin-6 may be involved. In severely burned patients, we have found that CBG was markedly decreased within a few hours postinjury. This decrease lasted about 2 weeks and was accompanied by an increase in the free fraction of serum cortisol. In addition, serum CBG responded to dietary manipulation in these patients, with low fat feeding resulting in higher serum CBG concentrations and lower serum-free cortisol values. This finding suggests that during severe stress, CBG may be important in regulating the amount of cortisol reaching target tissues such as the immune system and wounds.