Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice.
Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice.
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T 细胞受体 (TCR)-α 和 TCR-δ 缺陷小鼠中的隐孢子虫感染。
DOI：
10.1128/iai.64.5.1854-1857.1996
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发表时间：
1996
影响因子：
3.1
通讯作者：
Harp,JA
中科院分区：
文献类型：
--
作者：
Waters,WR;Harp,JA
缺乏α-β或γ-δ T细胞的小鼠比对照小鼠更容易感染原生动物寄生虫隐孢子虫。新生儿和成年α β-T细胞缺陷小鼠均发生慢性感染。γ-δ-T细胞缺陷的新生小鼠比对照小鼠更易感，但能够清除感染。成年γ δ-T细胞缺陷小鼠不易感染。这些数据表明，α β T细胞对于抵抗C。而γ δ T细胞具有不太重要的作用。
Mice deficient in either alpha beta or gamma delta T cells were more susceptible to infection with the protozoan parasite Cryptosporidium parvum than were control mice. Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infection. Gamma delta-T-cell-deficient neonatal mice were more susceptible than control mice but were able to clear the infection. Adult gamma delta-T-cell-deficient mice were not susceptible to infection. These data indicate that alpha beta T cells are important for resistance to C. parvum while gamma delta T cells have a less critical role.