Association between hepatitis C virus core protein and carotid atherosclerosis
Association between hepatitis C virus core protein and carotid atherosclerosis
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DOI：
10.1253/circj.67.26
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发表时间：
2003-01-01
影响因子：
3.3
通讯作者：
Yamakado, M
中科院分区：
文献类型：
--
作者：
Ishizaka, Y;Ishizaka, N;Yamakado, M
有人提出某些传染性微生物与动脉粥样硬化疾病风险增加之间存在联系。通过分析接受过一般健康筛查测试的受试者的数据，先前已报道颈动脉粥样硬化与丙型肝炎病毒（HCV）抗体血清阳性之间可能存在关联。在本研究中，评估了颈动脉粥样硬化与 HCV 核心蛋白阳性之间的可能联系，因为它被认为是病毒血症和持续感染的更好标志。在 1992 名入组受试者中，496 名（25%）有颈动脉斑块，25 名（1.3%）HCV 核心蛋白呈阳性。核心蛋白阴性和核心蛋白阳性受试者中颈动脉斑块呈阳性的比例分别为 480/1967 (24%) 和 16/25 (64%) (p
A link between certain infectious microorganisms and an increased risk of atherosclerotic disease has been suggested. By analyzing the data of subjects who had undergone general health-screening tests, a possible association between carotid atherosclerosis and seropositivity of antibody against hepatitis C virus (HCV) has been previously reported. In the present study, a possible link between carotid atherosclerosis and HCV core protein positivity was assessed, because it is postulated to be a better marker of viremia and thus persistent infection. Of the 1992 enrolled subjects, 496 (25%) had carotid artery plaque, and 25 (1.3%) were positive for HCV core protein. Carotid artery plaque was positive in 480/1967 (24%) and 16/25 (64%) of the core protein-negative and core protein-positive subjects, respectively (p