Infant-onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention plus)
Infant-onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention plus)
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DOI：
10.1016/j.jaci.2009.10.055
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发表时间：
2010-02-01
影响因子：
14.2
通讯作者：
Heinrich, Joachim
中科院分区：
文献类型：
--
作者：
Schmitt, Jochen;Apfelbacher, Christian;Heinrich, Joachim
工作背景：横断面研究表明湿疹和心理健康问题之间的关联，但时间关系尚不清楚。Objective：为了评估婴儿发病湿疹和心理健康问题之间的关联在前瞻性study.Methods：1995年和1998年之间，出生队列研究，招募和随访，直到10岁。医生诊断的湿疹，合并症，和广泛的环境暴露进行了评估，在年龄1，2，3，4，6和10岁。首先，我们根据优势和困难问卷调查了婴儿湿疹（1-2岁）和10岁时心理健康问题之间的关系。其次，我们分析了10岁时心理健康问题与湿疹病程的关系。结果：共有2916名婴儿符合分析条件。与从未被诊断为湿疹的参与者相比，患有婴儿湿疹的儿童在10岁时可能/可能的心理健康问题（优势和困难问卷总分）（比值比，1.49; 95%CI，1.13-1.96）和情绪症状（比值比，1.62; 95%CI，1.25-2.09）的风险显著增加。仅限于婴儿期的过度兴奋预测10岁时行为问题的风险显著更高。湿疹和情绪问题之间的关联在10岁的强度增加湿疹persistence.Conclusion：湿疹婴儿在10岁时心理健康问题的风险增加。即使之后清除，1至2岁的湿疹可能会导致持续的情绪和行为困难。（J Allergy Clin Immunol 2010;125：404-10.）
Background: Cross-sectional studies suggest an association between eczema and mental health problems, but the temporal relationship is unclear.Objective: To assess the association between infant-onset eczema and mental health problems in a prospective study.Methods: Between 1995 and 1998, a birth cohort study was recruited and followed until age 10 years. Physician-diagnosed eczema, comorbidities, and a broad set of environmental exposures were assessed at age 1, 2, 3, 4, 6, and 10 years. First, we investigated the association between infant-onset eczema (age 1-2 years) and mental health problems at age 10 years according to the Strengths and Difficulties Questionnaire. Second, we analyzed the likelihood of mental health problems at age 10 years in relation to the course of eczema.Results: A total of 2916 infants were eligible for analysis. Compared with participants never diagnosed as having eczema, children with infant-onset eczema had a significantly increased risk for possible/probable mental health problems (Strengths and Difficulties Questionnaire total score) at age 10 years (odds ratio, 1.49; 95% CI, 1.13-1.96) and for emotional symptoms (odds ratio, 1.62; 95% CI, 1.25-2.09). Eczema limited to infancy predicted a significantly higher risk for conduct problems at age 10 years. The strength of the association between eczema and emotional problems at age 10 years increased with increasing eczema persistence.Conclusion: Infants with eczema are at increased risk for mental health problems at age 10 years. Even if cleared afterward, eczema at age 1 to 2 years may cause persistent emotional and behavioral difficulties. (J Allergy Clin Immunol 2010;125:404-10.)