ANTITUMOR AND IMMUNOMODULATORY ACTIVITY OF INTRAPERITONEAL IFN-GAMMA IN OVARIAN-CARCINOMA PATIENTS WITH MINIMAL RESIDUAL TUMOR AFTER CHEMOTHERAPY
ANTITUMOR AND IMMUNOMODULATORY ACTIVITY OF INTRAPERITONEAL IFN-GAMMA IN OVARIAN-CARCINOMA PATIENTS WITH MINIMAL RESIDUAL TUMOR AFTER CHEMOTHERAPY
复制标题
DOI：
10.1002/ijc.2910510109
复制
发表时间：
1992-04-22
影响因子：
6.4
通讯作者：
ALLAVENA, P
中科院分区：
文献类型：
--
作者：
COLOMBO, N;PECCATORI, F;ALLAVENA, P
8例化疗后持续存在的上皮性卵巢癌患者，选择残留肿瘤直径不大于1 cm，经腹腔内（i. p.）每周两次用重组干扰素γ治疗3个月。所有患者的毒性包括发热和不适，3例患者的肝酶水平一过性升高。以细胞系为靶细胞，研究了外周血和腹腔肿瘤相关淋巴细胞（TAL）和巨噬细胞（TAM）的细胞毒功能。1.p. IFN-γ增强淋巴细胞和单核吞噬细胞的细胞毒性活性：与血液效应物相比，使用TAL和偶尔使用TAM时观察到的刺激更明显且更频繁，这表明在肿瘤生长和IFN给药部位优先调节。剖腹手术显示1例患者完全缓解，2例部分缓解，2例疾病稳定，3例疾病进展。在这个小系列的患者中，IFN-γ的免疫调节与临床反应之间没有明显的严格相关性。这些结果表明，与其在晚期卵巢癌中缺乏活性相反，IFN-γ在有限肿瘤负荷的存在下具有明确的免疫调节和抗肿瘤活性。
Eight patients with epithelial ovarian carcinoma persisting after chemotherapy, selected for having a residual tumor no larger than 1 cm in diameter, were treated intra-peritoneally (i.p.) with recombinant interferon-gamma twice weekly for 3 months. Toxicity consisted of fever and malaise in all patients and a transient rise in hepatic enzyme levels in 3 patients. The cytotoxic function of peripheral blood and peritoneal tumor-associated lymphocytes (TAL) and macrophages (TAM), was studied using cell lines as targets. 1.p. IFN-gamma augmented the cytotoxic activity of lymphocytes and mononuclear phagocytes: stimulation was more marked and more frequently observed with TAL and occasionally TAM than with blood effectors, suggesting preferential modulation at the site of tumor growth and IFN administration. Surgical laparotomy revealed that 1 patient had a complete response, 2 a partial response and 2 had stable disease, while 3 patients had progressive disease. In this small series of patients there was no obvious, strict correlation between immunomodulation by IFN-gamma and clinical response. These results indicate that, in contrast to its lack of activity in advanced ovarian carcinoma, IFN-gamma has definite immunomodulatory and antitumor activity in the presence of limited tumor burden.