Antineoplastic agents .362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana
Antineoplastic agents .362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana
复制标题
DOI：
10.1021/np9606106
复制
发表时间：
1997-02-01
影响因子：
5.1
通讯作者：
Boyd, MR
中科院分区：
文献类型：
--
作者：
Pettit, GR;McNulty, J;Boyd, MR
使用人类肿瘤细胞系进行生物测定引导的分离程序，从塞舌尔共和国海绵 Phakellia mauritiana 中分离出二溴法凯尔他汀 (4)。对其分离、X射线晶体结构解析、绝对立体化学和抗肿瘤活性进行了总结。 P. mauritiana 还被发现含有二溴邻苯二甲酰蛋白 (dibromophakellin) (1)、去溴膜质糖苷 (debromohymenialosine) (2)、胸苷、脱氧尿苷和胸腺嘧啶。
Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.