The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*
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DOI：
10.1186/s12917-020-02451-y
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发表时间：
2020-07-14
影响因子：
6.3
通讯作者：
Wurbel, Hanno
中科院分区：
文献类型：
--
作者：
du Sert, Nathalie Percie;Hurst, Viki;Wurbel, Hanno
可复制的科学需要透明的报告。ARRIVE指南（动物研究：体内实验报告）最初于2010年制定，旨在改善动物研究报告。它们包括一个信息清单，包括在描述体内实验的出版物中，使其他人能够充分审查工作，评估其方法的严谨性，并复制方法和结果。尽管多年来资助者和期刊的认可程度相当高，但对指南的遵守并不一致，动物研究出版物报告质量的预期改善也没有实现。在这里，我们介绍ARRIVE 2.0。对准则进行了更新，并对信息进行了重新编排，以便于在实践中使用。我们使用了一个德尔菲练习来区分优先级，并将指南的项目分为两组，“到达基本10”，这构成了最低要求，和“推荐集”，它描述了研究背景。该部门通过支持逐步实施的方法，促进了动物研究报告的改进。这有助于期刊编辑和审稿人核实最重要的项目是否在手稿中报告。我们还开发了随附的解释和验证文档，用于（1）解释指南中每个项目的原理，（2）澄清关键概念，以及（3）提供说明性示例。我们的目标是，通过这些变化，以帮助确保研究人员，审稿人和期刊编辑更好地装备，以提高科学过程的严谨性和透明度，从而提高可重复性。
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the "ARRIVE Essential 10," which constitutes the minimum requirement, and the "Recommended Set," which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.