PROGNOSTIC VALUE OF EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN CERVICAL-CARCINOMA
PROGNOSTIC VALUE OF EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN CERVICAL-CARCINOMA
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DOI：
10.1136/jcp.46.2.149
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发表时间：
1993-02-01
影响因子：
3.4
通讯作者：
WILCOX, FL
中科院分区：
文献类型：
--
作者：
HALE, RJ;BUCKLEY, CH;WILCOX, FL
目的：为探讨表皮生长因子受体在三种主要类型的宫颈癌中的表达模式及其预后价值，方法：对62例IB/IIA期宫颈癌进行了研究，所有病例均随访至少5年。有代表性的部分进行染色粘蛋白，以允许准确的肿瘤分型和一个标准的抗生物素蛋白-生物素免疫过氧化物酶技术使用的多克隆抗体12 E被用来证明表皮生长因子receptor.Results的存在：所有三种肿瘤类型的比例表达表皮生长因子受体，它是最常见的鳞状细胞癌（50%）。总的来说，表皮生长因子表达与死亡率之间存在相关性。这在没有淋巴结转移的情况下尤其明显。当个别肿瘤类型被认为与预后的这种关联是不明显的鳞状细胞癌或腺癌，但腺鳞癌是一个非常突出的特点adenosquamycarcinoma.Conclusions：表皮生长因子受体表达的免疫组化证明可能是有用的，在确定这些患者的预后不良，特别是那些与腺鳞癌没有转移到区域淋巴结。
Aims: To investigate the pattern of epidermal growth factor receptor expression and its prognostic value in the three main types of cervical carcinoma.Methods: 62 cases of stage IB/IIA cervical carcinoma, all with a minimum of five years of follow up, were studied. Representative sections were stained for mucin to permit accurate tumour typing and a standard avidin-biotin immunoperoxidase technique using the polyclonal antibody 12E was used to demonstrate the presence of epidermal growth factor receptor.Results: A proportion of all three tumour types expressed epidermal growth factor receptor, it being most common in squamous cell carcinomas (50%). Overall, there was a correlation between epidermal growth factor expression and mortality. This was particularly obvious in the absence of lymph node metastases. When the individual tumour types were considered this association with prognosis was not demonstrable for squamous cell carcinomas or adenocarcinomas but was a very prominent feature of adenosquamous carcinomas.Conclusions: Immunohistochemical demonstration of epidermal growth factor receptor expression may be useful in identifying those patients with a poor prognosis, particularly those with adenosquamous carcinomas which have not metastasised to the regional lymph nodes.