IS THE MULTIDRUG TRANSPORTER A FLIPPASE
IS THE MULTIDRUG TRANSPORTER A FLIPPASE
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DOI：
10.1016/0968-0004(92)90419-a
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发表时间：
1992-01-01
影响因子：
13.8
通讯作者：
GOTTESMAN, MM
中科院分区：
文献类型：
--
作者：
HIGGINS, CF;GOTTESMAN, MM
多药耐药现象与膜蛋白P-糖蛋白的存在有关，P-糖蛋白将各种药物泵出细胞，从而降低其毒性。 然而，这种泵送作用的机制仍不清楚。 在这篇文章中，我们认为，多药物转运蛋白的几个属性可以解释，如果它作为一个“翻转酶”运输药物从内小叶的脂质双层的外部或外部介质。
The phenomenon of multidrug resistance is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. However, the mechanism of this pumping action remains unclear. In this article, we suggest that several properties of the multidrug transporter may be explained if it acts as a 'flippase' to transport drugs from the inner leaflet of the lipid bilayer to the outer or to the external medium.