Doses to critical organs following radiotherapy and concomitant imaging of the larynx and breast
Doses to critical organs following radiotherapy and concomitant imaging of the larynx and breast
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DOI：
10.1259/bjr/32814323
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发表时间：
2007-12-01
影响因子：
2.6
通讯作者：
Moore, M.
中科院分区：
文献类型：
--
作者：
Harrison, R. M.;Wilkinson, M.;Moore, M.
适形放射治疗的发展意味着在整个治疗过程中的各个阶段增加成像程序的数量，主要是为了验证某些或所有治疗部分。这就提出了这些额外成像暴露的益处与由此产生的放射致癌相关风险之间的平衡问题。因此，有必要了解已估计个体致癌风险的关键器官的剂量。在这项研究中，这些器官的剂量已被测量与氟化锂热释光剂量计加载在拟人幻影，并进行逼真的放射治疗的喉和乳房，包括伴随CT和电子射野成像曝光与这些治疗的定位和验证。即使对于任一模态的大量伴随图像，由在每个部分的成像引起，来自放射治疗本身的泄漏和散射被示出为主导总体器官Q剂量，其中成像程序通常贡献总器官剂量的5-20%。
The development of conformal radiotherapy carries with it the implication of an increased number of imaging procedures at various stages throughout the overall treatment, principally for verification at some, or all, of the treatment fractions. This raises the issue of the balance between the benefit of these additional imaging exposures and the associated risk of radiocarcinogenesis arising from them. As such, it is necessary to appreciate the doses to critical organs for which individual carcinogenic risks have been estimated. In this study, doses to these organs have been measured with lithium fluoride thermoluminescence dosimetry loaded in anthropomorphic phantoms and subjected to realistic radiotherapy treatments of the larynx and breast, including concomitant CT and electronic portal imaging exposures associated with localization and verification of these treatments. Even for large numbers of concomitant images of either modality, arising from imaging at every fraction, the leakage and scatter from the radiotherapy itself is shown to dominate the overall organ Q dose, with imaging procedures generally contributing 5-20% of the total organ dose.