Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na,K-ATPase in kidney
Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na,K-ATPase in kidney
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DOI：
10.1007/s10863-005-9475-y
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发表时间：
2005-12-01
影响因子：
3
通讯作者：
Sweadner, KJ
中科院分区：
文献类型：
--
作者：
Arystarkhova, E;Sweadner, KJ
最近发现的一个单跨膜蛋白家族（FXYD蛋白）为Na，K-ATP酶的调控这一相当复杂的领域引入了一个新的方向。该家族至少有6个成员以细胞和组织特异性方式与Na，K-ATP酶结合，而其中4个，即γ亚基（FXYD 2）、CHIF（FXYD 4）、磷脂酶原（FXYD 1）和dysadherin（FXYD 5）已在肾脏中鉴定。这四种表达系统对异源表达系统的特性都有不同的影响。沿着它们在肾单位中的非重叠表达模式，这为在许多论文中报道的Na，K-ATP酶的片段特异性性质提供了潜在的结构基础。这篇简短的综述总结了我们自己的贡献油的结构/功能表征的家庭成员之一，γ亚基（FXYD 2）。重点是γ的剪接变体，它们的结构相似性和赋予Na，K-ATP酶的不同作用。
The recent discovery of a family of single-span membrane proteins (the FXYD proteins) introduced a new direction to the rather complicated area Of regulation of Na,K-ATPase. At least six members of the family have been shown to associate with the Na,K-ATPase in a cell- and tissue-specific manner, While four of them, namely the gamma subunit (FXYD2), CHIF (FXYD4), phospholemman (FXYD1), and dysadherin (FXYD5) have been identified in kidney. All four exhibited different effects oil the properties Of the PUMP ill heterologous expression systems. Taken along with their non-overlapping expression patterns in the nephron, this provides a potential structural basis for the segment-specific properties of the Na,K-ATPase that had been reported in a number of papers oil kidney physiology. This brief review summarizes our own contributions oil structure/functional Characterization of one of the family members, the gamma subunit (FXYD2). The focus is on splice variants of gamma, their structural similarity and yet distinct effects conferred to Na,K-ATPase.