Structural organization of the Golgi apparatus
Structural organization of the Golgi apparatus
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DOI：
10.1016/j.ceb.2010.10.004
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发表时间：
2011-02-01
影响因子：
7.5
通讯作者：
Lowe, Martin
中科院分区：
文献类型：
--
作者：
Lowe, Martin
高尔基体是真核生物的一个普遍特征，其主要功能是对新合成的膜蛋白和分泌蛋白进行加工、分选和运输。高尔基体有一个明确的结构，包括堆叠的扁平池膜，在脊椎动物中连接形成一条带。这种结构是如何维持的，以及它与高尔基体功能的关系一直是人们感兴趣的领域。在这篇评论中，我描述了最近的进展，在识别和表征的分子机器，共同帮助产生的特征组织的这个细胞器。
The Golgi apparatus is a universal feature of eukaryotes, carrying out the key functions of processing, sorting and trafficking of newly synthesized membrane and secretory proteins. The Golgi apparatus has a clearly defined structure, comprising stacks of flattened cisternal membranes that in Vertebrates are connected to form a ribbon. How this structure is maintained and how it relates to the functions of the Golgi apparatus has long been an area of interest. In this review I describe recent progress in the identification and characterization of the molecular machinery that together help generate the characteristic organization of this organelle.