Spatially Overlapping Regions Show Abnormal Thalamo-frontal Circuit and Abnormal Precuneus in Disorders of Consciousness
Spatially Overlapping Regions Show Abnormal Thalamo-frontal Circuit and Abnormal Precuneus in Disorders of Consciousness
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DOI：
10.1007/s10548-018-0693-0
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发表时间：
2019-02
期刊：
影响因子：
2.7
通讯作者：
Xiaoyan Wu;Qiuyou Xie;Xiaojin Liu;Huiyuan Huang;Qing Ma;Junjing Wang;Miao Zhong;Yanbin He;Chen Niu;Yan Chen;F. Deng;Xiaoxiao Ni;Yuan He;Yequn Guo;Ronghao Yu;Ruiwang Huang
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作者：
Xiaoyan Wu;Qiuyou Xie;Xiaojin Liu;Huiyuan Huang;Qing Ma;Junjing Wang;Miao Zhong;Yanbin He;Chen Niu;Yan Chen;F. Deng;Xiaoxiao Ni;Yuan He;Yequn Guo;Ronghao Yu;Ruiwang Huang
了解意识障碍（DOC）的神经机制是评估意识水平和诊断DOC患者的基础。尽管先前的研究报道了与意识相关的脑功能连接（FC）和自发神经活动模式，但它们之间的关系尚不清楚。在这项研究中，我们通过对15名DOC患者和24名健康对照的静息状态功能磁共振成像数据进行逐体素FC强度（FCS）和低频波动分数幅度（fALFF）分析，确定了DOC患者的异常脑区。此外，我们检测了两个测量之间的空间交叉点，并估计了FCS或fALFF与昏迷恢复量表修订（CRS-R）子量表之间的相关性。我们发现，DOC患者的右侧额上回、左侧丘脑和右侧楔前叶的局部FCS和fALFF低于健康对照组，这些区域与中游回路模型的区域一致。右侧楔前叶局部FCS/fALFF与CRS-R的运动和运动评分/运动评分呈显著正相关。我们的研究结果可能表明，自发性神经活动和丘脑额叶回路和楔前叶的功能连接的共发生模式与DOC患者的运动功能有关。
Understanding the neural mechanisms of disorders of consciousness (DOC) is essential for estimating the conscious level and diagnosing DOC patients. Although previous studies reported brain functional connectivity (FC) and spontaneous neural activity patterns associated with consciousness, the relationship between them remains unclear. In this study, we identified the abnormal brain regions in DOC patients by performing voxel-wise FC strength (FCS) and fractional amplitude of low-frequency fluctuations (fALFF) analyses on resting-state functional magnetic resonance imaging data of 15 DOC patients and 24 healthy controls. Furthermore, we detected spatial intersections between two measures and estimated the correlations between either the FCS or the fALFF and the subscales of the Coma Recovery Scale-Revised (CRS-R). We found that the right superior frontal gyrus, left thalamus and right precuneus in which the DOC patients had a lower local FCS and fALFF than healthy controls, are coincident with regions of the mesocircuit model. In the right precuneus, the local FCS/fALFF was significantly positively correlated with the oromotor and motor scores/motor score of the CRS-R. Our findings may indicate that the co-occurrent pattern of spontaneous neural activity and functional connectivity in the thalamo-frontal circuit and the precuneus are associated with motor function in DOC patients.