GenoWatch: a disease gene mining browser for association study
GenoWatch: a disease gene mining browser for association study
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DOI：
10.1093/nar/gkn214
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发表时间：
2008-07-01
影响因子：
14.9
通讯作者：
Yao, Adam
中科院分区：
文献类型：
--
作者：
Chen, Yan-Hau;Liu, Chuan-Kun;Yao, Adam
人类基因关联研究通常涉及多个基因组标记，如单核苷酸多态(SNPs)或短串联重复序列多态(SNP)，在研究过程中可能会识别出许多具有统计学意义的标记。基因观察可以从多个相关生物数据库中实时高效地批量提取关于多个标记及其相关基因的最新信息。检索到的基因信息包括基因本体论、功能、途径、疾病、PubMed相关文章等。随后的SNP功能影响分析和用于重新测序的目标基因的引物设计也可以在几次点击中完成。结果的展示经过了精心的设计，尽可能地对所有用户来说都是直观的。GenWatch可以在网站http://genepipe.ngc.sinica.edu.tw/genowatch.上找到
A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repeat polymorphisms, and many statistically significant markers may be identified during the study. GenoWatch can efficiently extract up-to-date information about multiple markers and their associated genes in batch mode from many relevant biological databases in real-time. The comprehensive gene information retrieved includes gene ontology, function, pathway, disease, related articles in PubMed and so on. Subsequent SNP functional impact analysis and primer design of a target gene for re-sequencing can also be done in a few clicks. The presentation of results has been carefully designed to be as intuitive as possible to all users.The GenoWatch is available at the website http://genepipe.ngc.sinica.edu.tw/genowatch.