Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy
Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy
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DOI：
10.1155/2019/9548324
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Szaflik, Jacek P.
中科院分区：
文献类型：
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作者：
Zaleska-Zmijewska, Anna;Wawrzyniak, Zbigniew M.;Szaflik, Jacek P.
背景资料。糖尿病视网膜病变(DR)是糖尿病患者视力受损的主要原因。使用自适应光学视网膜相机(rtx1(TM)；Imagine Eyes，法国)来捕捉来自Dr.Objective患者的视锥细胞和视网膜动脉的图像。对36例非增殖型糖尿病视网膜病变(NPDR，22例轻度NPDR，14例中度NPDR)和20例健康志愿者(对照组)的视锥参数(密度、光感受器间距和规律性)和视网膜动脉参数(管壁厚度、管腔直径、WLR和WCSA)进行分析。结果。糖尿病视网膜病变组偏心2度锥体密度明显低于对照组(分别为19822+/-4342个/mm(2)和24722+/-3507个/mm(2))。视锥密度和规律性随DR严重程度的增加而降低，DR组动脉壁明显增厚。糖尿病视网膜病变组和对照组的WLR值和WCSA值分别为0.339+/-0.06vs.0.254+/-0.04；WCSA5567+/-1140vs.4178+/-944。结论。轻、中度NPDR患者可见锥体规则和密度降低。视网膜小动脉的异常显示了微动脉功能障碍的迹象。rtx1的视网膜图像分析为糖尿病眼神经细胞和视网膜血管系统的早期变化提供了一种新的非侵入性测量方法。
Background. Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1 (TM); Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR. Objective. Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group). Results. Cone density at 2 degrees eccentricities was significantly lower in the DR compared to the control group (19822 +/- 4342 cells/mm(2) vs. 24722 +/- 3507 cells/mm(2), respectively). Cone density and regularity decreased with increasing severity of DR. The artery walls were significantly thicker in the DR group. The WLR and WCSA differed significantly between the DR and the control groups (WLR 0.339 +/- 0.06 vs. 0.254 +/- 0.04; WCSA 5567 +/- 1140 vs. 4178 +/- 944, respectively). Conclusions. Decreased cone regularity and density are seen in patients with mild and moderate NPDR. Abnormalities of retinal arterioles show signs of arteriolar dysfunction in DR. Retinal image analysis with the rtx1 offers a novel noninvasive measurement of early changes in the neural cells and retina vasculature in diabetic eyes.