Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.
Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.
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吸烟、慢性阻塞性肺疾病和小细胞肺癌之间的相关联系：国际肺癌联盟的汇总分析
DOI：
10.1016/j.ebiom.2015.09.031
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发表时间：
2015-11
期刊：
影响因子：
11.1
通讯作者：
Christiani DC
中科院分区：
文献类型：
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作者：
Huang R;Wei Y;Hung RJ;Liu G;Su L;Zhang R;Zong X;Zhang ZF;Morgenstern H;Brüske I;Heinrich J;Hong YC;Kim JH;Cote M;Wenzlaff A;Schwartz AG;Stucker I;Mclaughlin J;Marcus MW;Davies MP;Liloglou T;Field JK;Matsuo K;Barnett M;Thornquist M;Goodman G;Wang Y;Chen S;Yang P;Duell EJ;Andrew AS;Lazarus P;Muscat J;Woll P;Horsman J;Teare MD;Flugelman A;Rennert G;Zhang Y;Brenner H;Stegmaier C;van der Heijden EH;Aben K;Kiemeney L;Barros-Dios J;Pérez-Ríos M;Ruano-Ravina A;Caporaso NE;Bertazzi PA;Landi MT;Dai J;Hongbing Shen H;Fernandez-Tardon G;Rodriguez-Suarez M;Tardon A;Christiani DC
Backgroundsmall-cell lung cancer（SCLC）的高复发率和死亡率促使流行病学研究的需要，以帮助其prevent.MethodsWe纳入了ILCCO合作的24项研究。采用随机效应面板Logistic回归和三次样条回归估计吸烟行为对SCLC风险的影响，并探讨其非线性。此外，我们探讨了吸烟对小细胞肺癌的风险是否是通过COPD介导的。吸烟包年与SCLC风险急剧增加相关，包年范围为0至约50。与戒烟时间<5年的受试者相比，戒烟5 - 9年的受试者的SCLC风险降低了43%，戒烟≥ 20年的受试者为89%。与非COPD受试者相比，吸烟行为对COPD受试者中SCLC风险的影响显著更高，COPD患者的SCLC风险高1.86倍。此外，吸烟行为对小细胞肺癌的风险显着介导的COPD，占0.70%至7.55%的总effects. Interpretation这是最大的汇集研究，提供了更好的理解吸烟对小细胞肺癌，并进一步证明了因果关系的途径，通过COPD，值得进一步的实验研究。
BackgroundThe high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention.MethodsWe included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD.FindingsSignificant dose–response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5–9yearsto 89%quit_for_≥20yearsdeclined SCLC risk vs. subjects who had quit smoking <5years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects.InterpretationThis is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.
影响因子：
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作者：
Kim JH;Hong YC
通讯作者：
Hong YC