Ionic Covalent-Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection
Ionic Covalent-Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection
复制标题
离子共价有机框架纳米酶作为对抗细菌伤口感染的有效级联催化剂
DOI：
10.1002/smll.202100756
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发表时间：
2021-07-01
期刊：
影响因子：
13.3
通讯作者：
Jing, Xiabin
中科院分区：
文献类型：
--
作者：
Li, Yite;Wang, Lei;Jing, Xiabin
常规抗生素滥用的耐药性风险增加以及伤口表面形成的生物膜已被证明是细菌引起的感染和伤口愈合失败的主要问题。利用活性氧（如商业H2O2）进行处理是解决这些问题的可行方法，但其效率较低。本研究开发了一种具有自我促进抑菌作用和良好生物相容性的离子共价有机框架纳米酶（GFeF）作为葡萄糖触发的级联催化剂，用于治疗细菌性伤口感染。除了将葡萄糖有效转化为过氧化氢外，负载葡萄糖氧化酶生成的葡萄糖酸可以提供一个相容的催化环境，从而大大提高过氧化物酶的活性，从而产生更多的毒性羟基自由基。同时，带正电荷的GFeF与细菌膜之间的粘附可以大大增强愈合效果。这种葡萄糖触发的级联策略可以通过间接产生H2O2来减少有害的副作用，可能用于糖尿病患者的伤口愈合。
The increasing resistance risks of conventional antibiotic abuse and the formed biofilm on the surface of wounds have been demonstrated to be the main problems for bacteria-caused infections and unsuccessful wound healing. Treatment by reactive oxygen species, such as the commercial H2O2, is a feasible way to solve those problems, but limits in its lower efficiency. Herein, an ionic covalent-organic framework-based nanozyme (GFeF) with self-promoting antibacterial effect and good biocompatibility has been developed as glucose-triggered cascade catalyst against bacterial wound infection. Besides the efficient conversion of glucose to hydrogen peroxide, the produced gluconic acid by loading glucose oxidase can supply a compatible catalytic environment to substantially improve the peroxidase activity for generating more toxic hydroxyl radicals. Meanwhile, the adhesion between the positively charged GFeF and the bacterial membrane can greatly enhance the healing effects. This glucose-triggered cascade strategy can reduce the harmful side effects by indirectly producing H2O2, potentially used in the wound healing of diabetic patients.