Assessing the sensitivity to change of the OMERACT ultrasound structural gout lesions during urate-lowering therapy
Assessing the sensitivity to change of the OMERACT ultrasound structural gout lesions during urate-lowering therapy
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DOI：
10.1136/rmdopen-2019-001144
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发表时间：
2020-01-01
期刊：
影响因子：
6.2
通讯作者：
Terslev, Lene
中科院分区：
文献类型：
--
作者：
Christiansen, Sara Nysom;Ostergaard, Mikkel;Terslev, Lene
目的评价降尿酸治疗（URT）期间痛风患者超声结构性病变（根据流变学结果测量（OMERACT）超声组定义）变化的敏感性。方法对经显微镜证实的痛风患者进行超声检查（28个关节，26条肌腱），并在3个月和6个月后重复检查。通过超声评估关节和肌腱是否存在OMERACT结构性痛风病变-双轮廓征（DC）、痛风石、聚集物和侵蚀-进行二值评分。计算患者和病变水平的总分。在3个月和6个月的患者总评分和病变评分在不同locations.Results的变化50例（48名男性），平均年龄68.9（范围，30-88）岁，包括。超声显示DC和痛风石总和评分从0个月（分别为3.16和2.68）至3个月（2.33和2.43）和6个月（1.34和1.83）（双侧均为p1病变）的统计学显著性降低，此外，MTP 2 -4和膝关节是DC的常见部位，尤其是。同样，这些地区的位置与最显着的变化scores.Conclusion超声评估的OMERACT结构痛风病变评分binarily似乎是一个有用的工具，用于监测尿酸盐沉积在ULT. Particularly DC和痛风石仅3个月的治疗后显示出敏感性的变化。
Objectives To evaluate the sensitivity to change of ultrasound structural gout lesions, as defined by the Outcome Measures in Rheumatology (OMERACT) ultrasound group, in patients with gout during urate-lowering therapy (ULT).Methods Ultrasound (28 joints, 26 tendons) was performed in patients with microscopically verified gout initiating or increasing ULT and repeated after 3 and 6 months. Joints and tendons were evaluated by ultrasound for presence of the OMERACT structural gout lesions-double contour sign (DC), tophus, aggregates and erosion-scored binarily. A sum score was calculated at patient and lesion level. Changes at 3 and 6 months in patient sum scores and lesion scores at different locations were evaluated.Results 50 patients (48 men), mean age 68.9 (range, 30-88) years, were included. Ultrasound showed a statistically significant decrease in DC and tophus sum scores from 0 months (3.16 and 2.68, respectively) to 3 months (2.33 and 2.43) and 6 months (1.34 and 1.83) (all p1 lesions bilaterally), and furthermore MTP2-4 and knee joints were common sites especially for DC. Likewise, these regions were the locations with most pronounced changes in scores.Conclusion Ultrasound assessment of the OMERACT structural gout lesions scored binarily seems to be a useful tool for monitoring urate depositions during ULT. Particularly DC and tophus showed sensitivity to change after only 3 months of treatment.