Brazilian urban population genetic structure reveals a high degree of admixture
Brazilian urban population genetic structure reveals a high degree of admixture
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DOI：
10.1038/ejhg.2011.144
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发表时间：
2012-01-01
影响因子：
5.2
通讯作者：
Pereira, Alexandre C.
中科院分区：
文献类型：
--
作者：
Giolo, Suely R.;Soler, Julia M. P.;Pereira, Alexandre C.
基因分型技术的进步有助于更好地了解人类群体的遗传结构，并改善了关联研究的分析。为了分析巴西人类遗传变异的模式，我们使用了来自1129个个体的SNP数据，其中138个来自巴西圣保罗的城市人群，991个来自HapMap项目的11个人群。对这些群体共有的SNPs进行主成分分析，以确定捕获它们的遗传变异所需的SNPs的组成和数量。混合物和当地血统推断进行了巴西样本的个人。巴西样本中的个体介于欧洲人、墨西哥人和非洲人之间。巴西人被认为具有最高的内部遗传变异的抽样人群。我们的研究结果表明，正如预期的那样，分析的巴西样本来自美洲印第安人，非洲人和/或欧洲人的祖先，但不同种族的个体之间的通婚在产生广泛的遗传变异中发挥了重要作用。这些数据支持的概念，巴西人口，由于其高度的混合物，可以提供一个宝贵的资源，旨在使用混合物作为一种工具，映射复杂的性状在人类的战略。European Journal of Human Genetics（2012）20，111-116; doi：10.1038/ejhg.2011.144; 2011年8月24日在线发表
Advances in genotyping technologies have contributed to a better understanding of human population genetic structure and improved the analysis of association studies. To analyze patterns of human genetic variation in Brazil, we used SNP data from 1129 individuals - 138 from the urban population of Sao Paulo, Brazil, and 991 from 11 populations of the HapMap Project. Principal components analysis was performed on the SNPs common to these populations, to identify the composition and the number of SNPs needed to capture the genetic variation of them. Both admixture and local ancestry inference were performed in individuals of the Brazilian sample. Individuals from the Brazilian sample fell between Europeans, Mexicans, and Africans. Brazilians are suggested to have the highest internal genetic variation of sampled populations. Our results indicate, as expected, that the Brazilian sample analyzed descend from Amerindians, African, and/or European ancestors, but intermarriage between individuals of different ethnic origin had an important role in generating the broad genetic variation observed in the present-day population. The data support the notion that the Brazilian population, due to its high degree of admixture, can provide a valuable resource for strategies aiming at using admixture as a tool for mapping complex traits in humans. European Journal of Human Genetics (2012) 20, 111-116; doi:10.1038/ejhg.2011.144; published online 24 August 2011