INDUCTION OF MULLERIAN DUCT DERIVATIVES IN TESTICULAR FEMINIZED (TFM) MICE BY PRENATAL EXPOSURE TO DIETHYLSTILBESTROL
INDUCTION OF MULLERIAN DUCT DERIVATIVES IN TESTICULAR FEMINIZED (TFM) MICE BY PRENATAL EXPOSURE TO DIETHYLSTILBESTROL
复制标题
DOI：
10.1007/bf00300584
复制
发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
KOBAYASHI, S
中科院分区：
文献类型：
--
作者：
KOBAYASHI, S
携带Tfm突变基因的孕鼠在妊娠第9-16天注射己烯雌酚（DES），其野生雄性和Tfm雄性后代的米勒管衍生物的退化受到抑制。穆勒管衍生物的持续程度与DES剂量有关。在暴露于高剂量DES的动物中，观察到穆勒管完全或几乎完全保存。由于未注射母亲的Tfm雄性除了阴道外没有生殖道，尽管存在睾丸，但在产前暴露于DES后，Tfm雄性双侧出现了穆勒管衍生物，这表明这些动物的生殖道特征与正常雌性几乎相同。
When pregnant mice carrying the Tfm mutation gene were injected with diethylstilbestrol (DES) from days 9-16 of gestation, the regression of the Muellerian duct derivatives was inhibited in their wild male and Tfm male offspring. The degree of persistence of the Muellerian duct derivatives demonstrated a dependence on DES dose. Complete or almost complete preservation of the Muellerian ducts was observed in the animals exposed to high doses of DES. Since Tfm males from non-injected mothers had no reproductive tract except the vaginal anlage, despite the presence of testes, bilateral occurrence of the Muellerian duct derivatives in Tfm males following prenatal exposure to DES indicates that the characteristic features of the reproductive tract in these animals are almost the same as that in normal females.