Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
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DOI：
10.1016/j.numecd.2007.02.017
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发表时间：
2008-07-01
影响因子：
3.9
通讯作者：
Legrand, Philippe
中科院分区：
文献类型：
--
作者：
Paillard, Francois;Catheline, Daniel;Legrand, Philippe
背景和目的：在动物模型中，VLDL-甘油三酸酯的分泌高度依赖于硬脂酰-COA去饱和酶（SCD）活性，并且可以解释腹部肥大。目的是评估质棕榈酸含量（SCID活性的产物）与人类中甘油三酸酯血症和腹部肥胖的关系。方法：我们评估了134名健康男性。血浆棕榈酸含量被用作间接测量SCID活性，因为酶催化从饱和到单不饱和脂肪酸和棕榈油酸的摄入量的饱和度很小。甘油三酸酯的受试者> = 75％的受试者具有更高的棕榈酸含量。与甘油三酸酯
Background and aim: In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. The aim was to assess the relationship of plasma palmitoleic acid content, a product of SCID activity, with triglyceridemia and abdominal adiposity in humans.Methods: We evaluated 134 healthy men. Plasma palmitoleic acid content was used as an indirect measurement of SCID activity because that enzyme catalyzes the desaturation from saturated to monounsaturated fatty acids and palmitoleic acid intake is very small.Results: Subjects with triglycerides >= 75th percentile had a higher palmitoleic acid content than those with triglycerides